Tamoxifen maculopathy: The importance of screening and long follow-up.
Aged
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Breast Neoplasms
/ drug therapy
Female
Fluorescein Angiography
Follow-Up Studies
Humans
Macula Lutea
/ drug effects
Macular Degeneration
/ chemically induced
Monitoring, Physiologic
/ methods
Retinal Diseases
/ chemically induced
Tamoxifen
/ administration & dosage
Tomography, Optical Coherence
Breast cancer
Cancer du sein
Crystalline retinopathy
Dépistage oculaire
Macular telangiectasia
Maculopathie au tamoxifène
Ocular screening
Rétinopathie cristalline
Tamoxifen maculopathy
Télangiectasie maculaire
Journal
Journal francais d'ophtalmologie
ISSN: 1773-0597
Titre abrégé: J Fr Ophtalmol
Pays: France
ID NLM: 7804128
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
15
12
2019
accepted:
27
12
2019
pubmed:
6
7
2020
medline:
4
11
2020
entrez:
5
7
2020
Statut:
ppublish
Résumé
We report a case of a patient treated with tamoxifen 20mg daily as hormone therapy for breast cancer. On regular ophthalmological follow-up, tamoxifen maculopathy was detected on SD-OCT (Spectral Domain Optic Coherence Tomography, Carl Zeiss Meditec®), so the medication was discontinued. Despite discontinuation of the medication, the maculopathy progressed over time. We have been following our patient for seven years. Tamoxifen may produce a toxic maculopathy which may progress despite discontinuation of the medication. We consider our case interesting, given the lengthy follow-up of the patient with sequential SD-OCT images. To the best of our knowledge, our case represents the longest follow-up period for a patient with tamoxifen maculopathy. Moreover, we would like to stress the importance of screening in asymptomatic patients on this medication, in order to detect early pathological signs.
Identifiants
pubmed: 32620415
pii: S0181-5512(20)30267-9
doi: 10.1016/j.jfo.2019.12.004
pii:
doi:
Substances chimiques
Tamoxifen
094ZI81Y45
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
727-730Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.