Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.

Animals Clathrin Heavy Chains / metabolism Cytoplasmic Vesicles / metabolism Glucose Transporter Type 4 / metabolism Humans Models, Biological Ubiquitination
CHC22 clathrin ERGIC GLUT4 diabetes insulin membrane trafficking

Journal

Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566

Informations de publication

Date de publication:
09 2020
Historique:
received: 12 02 2020
revised: 24 05 2020
accepted: 27 05 2020
pubmed: 6 7 2020
medline: 25 6 2021
entrez: 5 7 2020
Statut: ppublish

Résumé

Insulin stimulates glucose transport by triggering regulated delivery of intracellular vesicles containing the GLUT4 glucose transporter to the plasma membrane. This process is defective in diseases such as type 2 diabetes (T2DM). While studies in rodent cells have been invaluable in understanding GLUT4 traffic, evolutionary plasticity must be considered when extrapolating these findings to humans. Recent work has identified species-specific distinctions in GLUT4 traffic, notably the participation of a novel clathrin isoform, CHC22, in humans but not rodents. Here, we discuss GLUT4 sorting in different species and how studies of CHC22 have identified new routes for GLUT4 trafficking. We further consider how different sorting-protein complexes relate to these routes and discuss other implications of these pathways in cell biology and disease.

Identifiants

DOI: 10.1016/j.tcb.2020.05.007 PMID: 32620516
pubmed: 32620516
pii: S0962-8924(20)30104-5
doi: 10.1016/j.tcb.2020.05.007
pii:
doi:

Substances chimiques

CLTCL1 protein, human 0
Glucose Transporter Type 4 0
Clathrin Heavy Chains 114899-12-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

705-719

Subventions

Organisme : Medical Research Council
ID : MR/S008144/1
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Gwyn W Gould (GW)

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK. Electronic address: gwyn.gould@strath.ac.uk.

Frances M Brodsky (FM)

Division of Biosciences, University College London, London WC1E 6BT, UK. Electronic address: f.brodsky@ucl.ac.uk.

Nia J Bryant (NJ)

Department of Biology and York Biomedical Research Institute, University of York, Heslington, York YO10 5DD, UK. Electronic address: nia.bryant@york.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Clathrine › Chaines lourdes de la clathrine › Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de glucose par diffusion facilitée › Transporteur de glucose de type 4 › Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › Building GLUT4 Vesicles: CHC22 Clathrin's Human Touch.