Defining a role for exercise training in the management of asthma.
Journal
European respiratory review : an official journal of the European Respiratory Society
ISSN: 1600-0617
Titre abrégé: Eur Respir Rev
Pays: England
ID NLM: 9111391
Informations de publication
Date de publication:
30 Jun 2020
30 Jun 2020
Historique:
received:
13
08
2019
accepted:
18
12
2019
entrez:
5
7
2020
pubmed:
6
7
2020
medline:
18
5
2021
Statut:
epublish
Résumé
The prevalence of asthma remains high worldwide, with increasing awareness of the morbidity and mortality from asthma in low-income countries. In the UK, despite the development of biological treatments, many patients remain suboptimally controlled, and mortality rates have been static for decades. Therefore, new approaches are needed to treat asthma that are scalable at minimal cost. Exercise immunology is an expanding field, and there is growing evidence that exercise can modulate inflammatory and immune processes in asthma. Whilst exercise is encouraged in current treatment guidelines, there are no specific recommendations as to the intensity, frequency or duration of exercise exposure. Despite national and international guidance to increase exercise, patients with asthma are less likely to engage in physical activity. This review explores the disease modifying benefit of exercise in asthma. We also review the domains in which exercise exerts positive clinical effects in asthma, including the effects of exercise on symptom scores, quality of life, psychosocial health, and in the obese asthma phenotype. Finally, we review the barriers to exercise in asthma, given the benefits it confers. A better understanding of the mechanisms through which exercise exerts its positive effects in asthma may provide more accurate prescription of exercise training programmes as part of broader asthma management, with the potential of identification of new drug targets.
Identifiants
pubmed: 32620584
pii: 29/156/190106
doi: 10.1183/16000617.0106-2019
pmc: PMC9489044
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright ©ERS 2020.
Déclaration de conflit d'intérêts
Conflict of interest: A.T. Freeman has nothing to disclose. Conflict of interest: K.J. Staples reports grants from GSK Biologicals and AstraZeneca, outside the submitted work. Conflict of interest: T.M.A. Wilkinson reports personal fees and other from MMH, grants and personal fees from GSK, AstraZeneca and Synairgen, and personal fees from Boehringer Ingelheim, outside the submitted work.
Références
PLoS One. 2016 Jun 13;11(6):e0157158
pubmed: 27294869
Am J Respir Crit Care Med. 2008 Aug 1;178(3):218-224
pubmed: 18480428
BMC Pulm Med. 2018 Jul 18;18(1):119
pubmed: 30021546
J Immunol. 2004 Apr 1;172(7):4520-6
pubmed: 15034069
Immunol Cell Biol. 2016 Feb;94(2):132-9
pubmed: 26563736
Eur Respir J. 2010 May;35(5):994-1002
pubmed: 19897558
Int J Environ Res Public Health. 2019 Jun 08;16(11):
pubmed: 31181728
Int J Tuberc Lung Dis. 2014 Nov;18(11):1269-78
pubmed: 25299857
Patient Prefer Adherence. 2018 Jun 15;12:1015-1023
pubmed: 29942118
J Asthma. 2019 Jan;56(1):87-94
pubmed: 29533692
Acad Pediatr. 2018 Apr;18(3):310-316
pubmed: 29309846
J Asthma. 2006 Mar;43(2):137-43
pubmed: 16517430
Respiration. 2011;81(4):302-10
pubmed: 20501982
Public Health. 2018 Jun;159:123-128
pubmed: 29571538
Sci Rep. 2019 Aug 19;9(1):12088
pubmed: 31427628
Thorax. 2015 Apr;70(4):376-8
pubmed: 24917087
Am J Respir Crit Care Med. 2017 Jan 1;195(1):32-42
pubmed: 27744739
Int J Sports Med. 2015 Jun;36(7):579-84
pubmed: 25837246
BMC Public Health. 2014 Mar 28;14:287
pubmed: 24673939
J Asthma. 2010 Mar;47(2):185-91
pubmed: 20170327
Immunol Cell Biol. 2000 Oct;78(5):496-501
pubmed: 11050532
CNS Neurol Disord Drug Targets. 2014;13(6):1002-14
pubmed: 24923346
Respir Med. 2007 Mar;101(3):638-44
pubmed: 16891108
PLoS One. 2015 Oct 07;10(10):e0138904
pubmed: 26445247
Curr Opin Allergy Clin Immunol. 2017 Jun;17(3):188-193
pubmed: 28333691
ERJ Open Res. 2019 Jun 24;5(2):
pubmed: 31249839
Redox Biol. 2019 Feb;21:101113
pubmed: 30738322
Wien Klin Wochenschr. 2017 Oct;129(19-20):655-664
pubmed: 28894957
Cochrane Database Syst Rev. 2013 Sep 30;(9):CD001116
pubmed: 24085631
J Asthma. 2013 Mar;50(2):109-16
pubmed: 23252987
Chest. 2010 Aug;138(2):331-7
pubmed: 20363839
Eur Respir J. 2011 Feb;37(2):318-23
pubmed: 20530042
Front Immunol. 2019 May 16;10:854
pubmed: 31156611
Clin Exp Allergy. 2013 Jan;43(1):36-49
pubmed: 23278879
Lancet. 2012 Dec 15;380(9859):2197-223
pubmed: 23245608
Postepy Dermatol Alergol. 2018 Dec;35(6):563-571
pubmed: 30618522
Am Rev Respir Dis. 1992 Apr;145(4 Pt 1):741-5
pubmed: 1554194
Pediatr Res. 2017 Aug;82(2):261-271
pubmed: 28796240
Int J Sports Med. 2012 May;33(5):402-9
pubmed: 22510803
Eur Respir J. 2008 Dec;32(6):1570-5
pubmed: 18684843
Ann Allergy Asthma Immunol. 2014 Aug;113(2):137-42
pubmed: 24986036
Curr Opin Allergy Clin Immunol. 2019 Apr;19(2):118-125
pubmed: 30601152
Metabolism. 2015 Feb;64(2):172-81
pubmed: 25458831
Iran J Allergy Asthma Immunol. 2005 Sep;4(3):133-8
pubmed: 17301436
Brain Behav Immun. 2013 Nov;34:67-78
pubmed: 23928286
Clin Exp Allergy. 2008 Jun;38(6):872-97
pubmed: 18498538
Pediatr Pulmonol. 2012 Jan;47(1):8-17
pubmed: 22170805
Scand J Med Sci Sports. 1998 Feb;8(1):27-32
pubmed: 9502307
Brain Behav Immun. 2010 Jan;24(1):153-9
pubmed: 19781626
J Asthma. 2018 May;55(5):555-560
pubmed: 28759275
Front Immunol. 2016 Jun 14;7:237
pubmed: 27379098
J Allergy Clin Immunol. 2015 Aug;136(2):454-61.e9
pubmed: 25748343
Respir Physiol Neurobiol. 2018 Jan;248:55-62
pubmed: 29224851
J Pediatr. 2003 Feb;142(2):179-84
pubmed: 12584541
Allergol Immunopathol (Madr). 2013 Mar-Apr;41(2):73-85
pubmed: 22771150
Thorax. 2015 Aug;70(8):732-9
pubmed: 26063507
BMC Pulm Med. 2019 Jul 24;19(1):134
pubmed: 31340793
Biomed Res Int. 2014;2014:429248
pubmed: 25050349
Curr Opin Pulm Med. 2020 Jan;26(1):77-83
pubmed: 31573988
J Appl Physiol (1985). 2019 Feb 1;126(2):413-421
pubmed: 30521428
Sports Med. 2013 Nov;43(11):1157-70
pubmed: 23846823
Allergy Asthma Clin Immunol. 2017 Jul 26;13:34
pubmed: 28769983
Respir Physiol Neurobiol. 2011 Mar 15;175(3):383-9
pubmed: 21236366
Scand J Med Sci Sports. 2016 Jan;26(1):82-92
pubmed: 25652754
J Asthma. 2018 Aug;55(8):868-876
pubmed: 28853952
Med Sci Sports Exerc. 2018 Jul;50(7):1367-1376
pubmed: 29432326
Am J Respir Cell Mol Biol. 2009 Jan;40(1):83-9
pubmed: 18635813
BMC Pulm Med. 2013 Jun 13;13:38
pubmed: 23758826
Med Sci Sports Exerc. 2011 Feb;43(2):197-203
pubmed: 20581719
J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):803-811
pubmed: 29133220
Brain Behav Immun. 2005 Sep;19(5):413-22
pubmed: 15922554
Am J Respir Crit Care Med. 2007 Nov 1;176(9):871-7
pubmed: 17690332
Obes Surg. 2017 Nov;27(11):3055-3060
pubmed: 28831733
Allergol Immunopathol (Madr). 2011 Mar-Apr;39(2):90-5
pubmed: 21242022