Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome.
Journal
European respiratory review : an official journal of the European Respiratory Society
ISSN: 1600-0617
Titre abrégé: Eur Respir Rev
Pays: England
ID NLM: 9111391
Informations de publication
Date de publication:
30 Jun 2020
30 Jun 2020
Historique:
received:
22
04
2020
accepted:
04
06
2020
entrez:
5
7
2020
pubmed:
6
7
2020
medline:
18
5
2021
Statut:
epublish
Résumé
Acute respiratory distress syndrome (ARDS) remains a significant source of mortality in critically ill patients. Characterised by acute, widespread alveolar inflammation and pulmonary oedema, its pathophysiological heterogeneity has meant that targeted treatments have remained elusive. Metabolomic analysis has made initial steps in characterising the underlying metabolic derangements of ARDS as an indicator of phenotypical class and has identified mitochondrial dysfunction as a potential therapeutic target. Mesenchymal stem cells and their derived extracellular vesicles have shown significant promise as potential therapies in delivering mitochondria in order to redivert metabolism onto physiological pathways.
Identifiants
pubmed: 32620587
pii: 29/156/200114
doi: 10.1183/16000617.0114-2020
pmc: PMC9488567
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/L017229/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R025096/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S009426/1
Pays : United Kingdom
Informations de copyright
Copyright ©ERS 2020.
Déclaration de conflit d'intérêts
Conflict of interest: M.J. Robinson has nothing to disclose. Conflict of interest: A.D. Krasnodembskaya reports grants from the UK Medical Research Council, during the conduct of the study.
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