The Expression Level of

Aged B7-H1 Antigen / genetics Biomarkers, Tumor / genetics Breast Neoplasms / genetics Disease-Free Survival Female Gene Expression Regulation, Neoplastic / genetics Humans Kaplan-Meier Estimate Neoplasm Recurrence, Local / genetics Prognosis RNA, Messenger / genetics
PD-L1 biomarker breast cancer liquid biopsy recurrence

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 16 05 2020
revised: 31 05 2020
accepted: 01 06 2020
entrez: 5 7 2020
pubmed: 6 7 2020
medline: 14 7 2020
Statut: ppublish

Résumé

Programmed death-ligand 1 (PD-L1/CD274) elicits T-cell anergy, leading to immune suppression. We aimed to determine the prognostic relevance of PD-L1 expression in the blood of breast cancer (BC) patients. We measured PD-L1 mRNA expression in blood and tumor tissues of BC patients using RT-qPCR and a dataset from The Cancer Genome Atlas, and performed a survival analysis of PD-L1 expression in the blood of 330 BC patients. Flow cytometric analysis was performed using blood cells. No statistical difference in PD-L1 expression was seen between normal controls and BC in blood or tissues. There was a significant positive correlation between the PD-L1 expression levels in blood and tissues. Decreased PD-L1 expression in blood or tissues was associated with poor recurrence-free survival. PD-L1 is mainly expressed in polymorphonuclear leukocytes. Low expression of PD-L1 in the blood could serve as a biomarker of poor prognosis in BC patients.

Sections du résumé

BACKGROUND/AIM OBJECTIVE
Programmed death-ligand 1 (PD-L1/CD274) elicits T-cell anergy, leading to immune suppression. We aimed to determine the prognostic relevance of PD-L1 expression in the blood of breast cancer (BC) patients.
MATERIALS AND METHODS METHODS
We measured PD-L1 mRNA expression in blood and tumor tissues of BC patients using RT-qPCR and a dataset from The Cancer Genome Atlas, and performed a survival analysis of PD-L1 expression in the blood of 330 BC patients. Flow cytometric analysis was performed using blood cells.
RESULTS RESULTS
No statistical difference in PD-L1 expression was seen between normal controls and BC in blood or tissues. There was a significant positive correlation between the PD-L1 expression levels in blood and tissues. Decreased PD-L1 expression in blood or tissues was associated with poor recurrence-free survival. PD-L1 is mainly expressed in polymorphonuclear leukocytes.
CONCLUSION CONCLUSIONS
Low expression of PD-L1 in the blood could serve as a biomarker of poor prognosis in BC patients.

Identifiants

DOI: 10.21873/anticanres.14362 PMID: 32620612
pubmed: 32620612
pii: 40/7/3733
doi: 10.21873/anticanres.14362
doi:

Substances chimiques

B7-H1 Antigen 0
Biomarkers, Tumor 0
CD274 protein, human 0
RNA, Messenger 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3733-3742

Informations de copyright

Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Takaaki Masuda (T)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Miwa Noda (M)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Akihiro Kitagawa (A)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Qingjiang Hu (Q)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Atsushi Fujii (A)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Shuhei Ito (S)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Keisuke Kosai (K)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Yuki Ando (Y)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Yoshihiro Matsumoto (Y)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Hajime Ohtsu (H)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Hiroki Uchida (H)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.

Shinji Ohno (S)

Breast Oncology Center, The Cancer Institute Hospital Ariake of Japanese Foundation for Cancer Research, Tokyo, Japan.

Koshi Mimori (K)

Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan kmimori@beppu.kyushu-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › The Expression Level of
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › The Expression Level of
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › The Expression Level of
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › The Expression Level of
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Survie sans rechute › The Expression Level of
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › The Expression Level of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Expression Level of
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Estimation de Kaplan-Meier › The Expression Level of
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › The Expression Level of
questionsmedicales.fr › Diagnostic › Pronostic › The Expression Level of
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › The Expression Level of