Association between Serum Essential Metal Elements and the Risk of Schizophrenia in China.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 07 2020
03 07 2020
Historique:
received:
11
10
2019
accepted:
19
04
2020
entrez:
5
7
2020
pubmed:
6
7
2020
medline:
17
12
2020
Statut:
epublish
Résumé
Numerous essential metal elements (EMEs) are necessary to maintain the proper function of human body. In this case-control study, we investigated the associations of 11 EMEs [Calcium (Ca), potassium (K), magnesium (Mg), sodium (Na), manganese (Mn), selenium (Se), cobalt (Co), Molybdenum (Mo), copper (Cu), zinc (Zn), and iron (Fe)] in serum with the risk of schizophrenia. We recruited first-episode and drug-naïve schizophrenic patients (cases = 99) and age-sex-matched normal subjects (controls = 99) from Tangshan, Hebei Province, China. The 11 EMEs in serum from cases and controls were quantified by inductively coupled plasma atomic emission spectrometry and inductively coupled plasma mass spectrometry. We observed that a higher level of Mn (OR = 2.390; 95%CI: 1.504-3.796) and lower levels of Ca (OR = 0.939; 95%CI: 0.890-0.990), Mg (OR = 0.806; 95%CI: 0.669-0.972), Na (OR = 0.995; 95%CI: 0.993-0.998), and Se (OR = 0.954; 95%CI: 0.937-0.972) were associated with an elevated risk of schizophrenia. Dose-response relationships between serum EME concentrations and the risk of schizophrenia were observed in most of the schizophrenia-associated EMEs. Moreover, the serum concentrations of these schizophrenia-associated EMEs in patients were correlated with the severity of their clinical symptoms. Significant correlations were found between EMEs and biomarkers associated with schizophrenia related to metabolic and oxidative stress. This study suggested that the concentration and profile of EMEs were different between schizophrenic patients and normal controls and revealed potential metabolisms associated with EMEs and schizophrenia, suggesting EMEs might act as biomarkers of schizophrenia to improve the current situation of diagnosis and treatment.
Identifiants
pubmed: 32620780
doi: 10.1038/s41598-020-66496-7
pii: 10.1038/s41598-020-66496-7
pmc: PMC7335092
doi:
Substances chimiques
Biomarkers
0
Metals
0
Trace Elements
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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