A call to action: Feasible strategies to reduce the discard of transplantable kidneys in the United States.
KDPI
kidney biopsy
organ allocation
organ discard
Journal
Clinical transplantation
ISSN: 1399-0012
Titre abrégé: Clin Transplant
Pays: Denmark
ID NLM: 8710240
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
30
04
2020
revised:
16
05
2020
accepted:
19
05
2020
pubmed:
6
7
2020
medline:
24
6
2021
entrez:
5
7
2020
Statut:
ppublish
Résumé
Changes to the United States kidney allocation system targeted at reducing organ discard have failed to improve organ utilization. High Kidney Donor Profile Index kidneys continue to be discarded at high rates as a result of the regulatory and financial barriers to widespread utilization of these organs. However, there are potential changes to clinical practice that could improve organ utilization. Expediting the time from initial offer to final organ acceptance would reduce cold ischemic time and should improve utilization. Implementation of procurement biopsy standards to avoid biopsy of low risk organs may prevent organ discards due to inaccurate data or excessive cold ischemia time. Further, standardization of procurement biopsy pathological interpretation coupled with electronic accessibility would enable early acceptance of difficult to transplant organs. These changes to allocation practice patterns are vital given proposals to expand the geographic sharing of deceased donor kidneys. Implementation of new allocation policies must be evaluated to ensure they result in higher transplant rates and acceptable post-transplant outcomes.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13990Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Bae S, Massie AB, Luo X, Anjum S, Desai NM, Segev DL. Changes in discard rate after the introduction of the Kidney Donor Profile Index (KDPI). Am J Transplant. 2016;16(7):2202-2207.
Aubert O, Reese PP, Audry B, et al. Disparities in acceptance of deceased donor kidneys between the United States and France and Estimated Effects of Increased US Acceptance. JAMA Intern Med. 2019;179(10):1365.
Stewart DE, Garcia VC, Rosendale JD, Klassen DK, Carrico BJ. Diagnosing the decades-long rise in the deceased donor kidney discard rate in the United States. Transplantation. 2017;101(3):575-587.
Reese PP, Harhay MN, Abt PL, Levine MH, Halpern SD. New solutions to reduce discard of kidneys donated for transplantation. J Am Soc Nephrol. 2016;27(4):973-980.
Serrano OK, Vock DM, Chinnakotla S, et al. The relationships between cold ischemia time, kidney transplant length of stay, and transplant-related costs. Transplantation. 2019;103(2):401-411.
Englesbe MJ, Ads Y, Cohn JA, et al. The effects of donor and recipient practices on transplant center finances. Am J Transplant. 2008;8(3):586-592.
Massie AB, Luo X, Chow EK, Alejo JL, Desai NM, Segev DL. Survival benefit of primary deceased donor transplantation with high-KDPI kidneys. Am J Transplant. 2014;14(10):2310-2316.
Mankowski MA, Kosztowski M, Raghavan S, et al. Accelerating kidney allocation: simultaneously expiring offers. Am J Transplant. 2019;19(11):3071-3078.
Ibrahim M, Vece G, Mehew J, et al. An international comparison of deceased donor kidney utilization: what can the US and UK learn from each other? Am J Transplant. 2020; 20:1309-1322.
Frei U, Noeldeke J, Machold-Fabrizii V, et al. Prospective age-matching in elderly kidney transplant recipients-a 5-year analysis of the Eurotransplant Senior Program. Am J Transplant. 2008;8(1):50-57.
Callaghan CJ, Harper SJ, Saeb-Parsy K, et al. The discard of deceased donor kidneys in the UK. Clin Transplant. 2014;28(3):345-353.
United Network for Organ Sharing. Kidney Accelerated Placement project for national offers begins July 18. https://optn.transplant.hrsa.gov/news/kidney-accelerated-placement-project-for-national-offers-begins-july-18. Accessed April 27, 2020.
Marrero WJ, Naik AS, Friedewald JJ, et al. Predictors of deceased donor kidney discard in the United States. Transplantation. 2017;101(7):1690-1697.
Mohan S, Chiles MC, Patzer RE, et al. Factors leading to the discard of deceased donor kidneys in the United States. Kidney Int. 2018;94(1):187-198.
Liapis H, Gaut JP, Klein C, et al. Banff histopathological consensus criteria for preimplantation kidney biopsies. Am J Transplant. 2017;17(1):140-150.
Kasiske BL, Stewart DE, Bista BR, et al. The role of procurement biopsies in acceptance decisions for kidneys retrieved for transplant. Clin J Am Soc Nephrol. 2014;9(3):562-571.
Wang CJ, Wetmore JB, Crary GS, Kasiske BL. The donor kidney biopsy and its implications in predicting graft outcomes: a systematic review. Am J Transplant. 2015;15(7):1903-1914.
Carpenter D, Husain SA, Brennan C, et al. Procurement biopsies in the evaluation of deceased donor kidneys. Clin J Am Soc Nephrol. 2018;13(12):1876-1885.
Muruve NA, Steinbecker KM, Luger AM. Are wedge biopsies of cadaveric kidneys obtained at procurement reliable? Transplantation. 2000;69(11):2384-2388.
Yong ZZ, Kipgen D, Aitken EL, Khan KH, Kingsmore DB. Wedge versus core biopsy at time zero: which provides better predictive value for delayed graft function with the Remuzzi histological scoring system? Transplant Proc. 2015;47(6):1605-1609.
Mazzucco G, Magnani C, Fortunato M, Todesco A, Monga G. The reliability of pre-transplant donor renal biopsies (PTDB) in predicting the kidney state. A comparative single-centre study on 154 untransplanted kidneys. Nephrol Dial Transplant. 2010;25(10):3401-3408.
Haas M, Segev DL, Racusen LC, et al. Arteriosclerosis in kidneys from healthy live donors: comparison of wedge and needle core perioperative biopsies. Arch Pathol Lab Med. 2008;132(1):37-42.
Hopfer H, Kemeny E. Assessment of donor biopsies. Curr Opin Organ Transplant. 2013;18(3):306-312.
Lentine KL, Naik AS, Schnitzler MA, et al. Variation in use of procurement biopsies and its implications for discard of deceased donor kidneys recovered for transplantation. Am J Transplant. 2019;19(8):2241-2251.
Naesens M. Zero-time renal transplant biopsies: a comprehensive review. Transplantation. 2016;100(7):1425-1439.
Azancot MA, Moreso F, Salcedo M, et al. The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors. Kidney Int. 2014;85(5):1161-1168.
Evans AJ, Chetty R, Clarke BA, et al. Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience. Hum Pathol. 2009;40(8):1070-1081.
Jukic DM, Drogowski LM, Martina J, Parwani AV. Clinical examination and validation of primary diagnosis in anatomic pathology using whole slide digital images. Arch Pathol Lab Med. 2011;135(3):372-378.
Gandolfini I, Buzio C, Zanelli P, et al. The Kidney Donor Profile Index (KDPI) of marginal donors allocated by standardized pretransplant donor biopsy assessment: distribution and association with graft outcomes. Am J Transplant. 2014;14(11):2515-2525.
Neil DA, Roberts IS, Bellamy CO, Wigmore SJ, Neuberger JM. Improved access to histopathology using a digital system could increase the organ donor pool and improve allocation. Transpl Int. 2014;27(8):759-764.