Efficacy of vitamin D

Adult Cholecalciferol / pharmacology Dietary Supplements / analysis Double-Blind Method Female HIV Infections / drug therapy Humans Incidence Intention to Treat Analysis Kaplan-Meier Estimate Male Placebos Tanzania Treatment Outcome Tuberculosis, Pulmonary / prevention & control Vitamin D / analogs & derivatives

Journal

The lancet. HIV
ISSN: 2352-3018
Titre abrégé: Lancet HIV
Pays: Netherlands
ID NLM: 101645355

Informations de publication

Date de publication:
07 2020
Historique:
received: 29 12 2019
revised: 31 03 2020
accepted: 01 04 2020
entrez: 5 7 2020
pubmed: 6 7 2020
medline: 1 9 2020
Statut: ppublish

Résumé

Observational data suggest that low vitamin D status is associated with an increased incidence of pulmonary tuberculosis and mortality among people living with HIV. The primary aims of this study were to assess the effect of vitamin D This was a randomised, double-blind, placebo-controlled trial of vitamin D Between Feb 24, 2014, and Feb 24, 2017, 6250 adults initiating ART had serum 25-hydroxyvitamin D screening, 4000 of whom were enrolled in the trial and followed up for 1 year (follow-up of all participants was completed on March 7, 2018). 2001 patients were randomly assigned to the vitamin D Additional research is needed before vitamin D National Institute of Diabetes and Digestive and Kidney Diseases.

Sections du résumé

BACKGROUND
Observational data suggest that low vitamin D status is associated with an increased incidence of pulmonary tuberculosis and mortality among people living with HIV. The primary aims of this study were to assess the effect of vitamin D
METHODS
This was a randomised, double-blind, placebo-controlled trial of vitamin D
FINDINGS
Between Feb 24, 2014, and Feb 24, 2017, 6250 adults initiating ART had serum 25-hydroxyvitamin D screening, 4000 of whom were enrolled in the trial and followed up for 1 year (follow-up of all participants was completed on March 7, 2018). 2001 patients were randomly assigned to the vitamin D
INTERPRETATION
Additional research is needed before vitamin D
FUNDING
National Institute of Diabetes and Digestive and Kidney Diseases.

Identifiants

DOI: 10.1016/S2352-3018(20)30108-9 PMID: 32621874 PMC: PMC7433214
pubmed: 32621874
pii: S2352-3018(20)30108-9
doi: 10.1016/S2352-3018(20)30108-9
pmc: PMC7433214
mid: NIHMS1610275
pii:
doi:

Substances chimiques

Placebos 0
Vitamin D 1406-16-2
Cholecalciferol 1C6V77QF41
25-hydroxyvitamin D A288AR3C9H

Banques de données

ClinicalTrials.gov
['NCT01798680']

Types de publication

Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e463-e471

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK098075
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Références

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Auteurs

Christopher R Sudfeld (CR)

Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. Electronic address: csudfeld@hsph.harvard.edu.

Ferdinand Mugusi (F)

Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Alfa Muhihi (A)

Management and Development for Health, Dar es Salaam, Tanzania.

Said Aboud (S)

Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Tumaini J Nagu (TJ)

Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Nzovu Ulenga (N)

Management and Development for Health, Dar es Salaam, Tanzania.

Biling Hong (B)

Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.

Molin Wang (M)

Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Wafaie W Fawzi (WW)

Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Efficacy of vitamin D
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholécalciférol › Efficacy of vitamin D
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Efficacy of vitamin D
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Méthode en double aveugle › Efficacy of vitamin D
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Efficacy of vitamin D
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Efficacy of vitamin D
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Efficacy of vitamin D
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Analyse en intention de traitement › Efficacy of vitamin D
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Estimation de Kaplan-Meier › Efficacy of vitamin D
questionsmedicales.fr › Thérapeutique › Placebo › Efficacy of vitamin D
questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Afrique de l'Est › Tanzanie › Efficacy of vitamin D
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Efficacy of vitamin D
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Tuberculose pulmonaire › Efficacy of vitamin D
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › Efficacy of vitamin D