Reversible anti-TNFα treatment induced dementia: A case report.

Antirheumatic Agents / adverse effects Dementia / chemically induced Humans Spondylitis, Ankylosing / drug therapy Treatment Outcome Tumor Necrosis Factor Inhibitors / adverse effects
Anti-TNFα Drug induced dementia Rapidly progressive dementia

Journal

Joint bone spine
ISSN: 1778-7254
Titre abrégé: Joint Bone Spine
Pays: France
ID NLM: 100938016

Informations de publication

Date de publication:
01 2021
Historique:
received: 03 02 2020
accepted: 17 06 2020
pubmed: 6 7 2020
medline: 29 6 2021
entrez: 5 7 2020
Statut: ppublish

Résumé

We report the first case of a reversible rapidly progressive dementia occurring in a patient with ankylosing spondylitis, a few months after the beginning of a TNFα inhibitor treatment (TNFi). The exhaustive neurologic explorations were negative. No etiology was found to explain dementia. The dementia slowly improved after TNFi withdrawal. The chronology of this observation suggests a responsibility of the TNFi in the dementia manifestations.

Identifiants

DOI: 10.1016/j.jbspin.2020.06.017 PMID: 32622041
pubmed: 32622041
pii: S1297-319X(20)30129-9
doi: 10.1016/j.jbspin.2020.06.017
pii:
doi:

Substances chimiques

Antirheumatic Agents 0
Tumor Necrosis Factor Inhibitors 0

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

105044

Informations de copyright

Copyright © 2020. Published by Elsevier Masson SAS.

Auteurs

Camille Hou (C)

Neurology department, Rennes University, Rennes, France.

Emmanuel Azzi (E)

Rheumatology department, Rennes University, CHU de Rennes Hôpital Sud, 35056 Rennes, France.

Anne Salmon (A)

Neurology department, Rennes University, Rennes, France.

Marie-Noëlle Osmont (MN)

Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, Department of Clinical Pharmacology, Rennes University, Rennes, France.

Aleth Perdriger (A)

Rheumatology department, Rennes University, CHU de Rennes Hôpital Sud, 35056 Rennes, France. Electronic address: aleth.perdriger@chu-rennes.fr.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antirhumatismaux › Reversible anti-TNFα treatment induced...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Reversible anti-TNFα treatment induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reversible anti-TNFα treatment induced...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies articulaires › Arthrite › Spondylarthrite › Spondylarthropathies › Spondyloarthrite axiale › Pelvispondylite rhumatismale › Reversible anti-TNFα treatment induced...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Reversible anti-TNFα treatment induced...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Inhibiteurs du facteur de nécrose tumorale › Reversible anti-TNFα treatment induced...