A retrospective multicenter study of fatal pediatric melanoma.

Adolescent Adult Child Child, Preschool Female Humans Infant Male Melanoma / diagnosis Retrospective Studies Skin Neoplasms / diagnosis Young Adult

melanoma oncology pediatric dermatology pediatric melanoma

Journal

Journal of the American Academy of Dermatology

ISSN: 1097-6787

Titre abrégé: J Am Acad Dermatol

Pays: United States

ID NLM: 7907132

Informations de publication

Date de publication:
Nov 2020

Historique:

received: 22 04 2020

revised: 23 06 2020

accepted: 29 06 2020

pubmed: 6 7 2020

medline: 10 4 2021

entrez: 5 7 2020

Statut: ppublish

Résumé

Pediatric melanoma is rare and diagnostically challenging. To characterize clinical and histopathologic features of fatal pediatric melanomas. Multicenter retrospective study of fatal melanoma cases in patients younger than 20 years diagnosed between 1994 and 2017. Of 38 cases of fatal pediatric melanoma identified, 57% presented in white patients and 19% in Hispanic patients. The average age at diagnosis was 12.7 years (range, 0.0-19.9 y), and the average age at death was 15.6 years (range, 1.2-26.2 y). Among cases with known identifiable subtypes, 50% were nodular (8/16), 31% were superficial spreading (5/16), and 19% were spitzoid melanoma (3/16). One fourth (10/38) of melanomas arose in association with congenital melanocytic nevi. Retrospective nature, cohort size, and potential referral bias. Pediatric melanoma can be fatal in diverse clinical presentations, including a striking prevalence of Hispanic patients compared to adult disease, and with a range of clinical subtypes, although no fatal cases of spitzoid melanoma were diagnosed during childhood.

Sections du résumé

BACKGROUND BACKGROUND

Pediatric melanoma is rare and diagnostically challenging.

OBJECTIVE OBJECTIVE

To characterize clinical and histopathologic features of fatal pediatric melanomas.

METHODS METHODS

Multicenter retrospective study of fatal melanoma cases in patients younger than 20 years diagnosed between 1994 and 2017.

RESULTS RESULTS

Of 38 cases of fatal pediatric melanoma identified, 57% presented in white patients and 19% in Hispanic patients. The average age at diagnosis was 12.7 years (range, 0.0-19.9 y), and the average age at death was 15.6 years (range, 1.2-26.2 y). Among cases with known identifiable subtypes, 50% were nodular (8/16), 31% were superficial spreading (5/16), and 19% were spitzoid melanoma (3/16). One fourth (10/38) of melanomas arose in association with congenital melanocytic nevi.

LIMITATIONS CONCLUSIONS

Retrospective nature, cohort size, and potential referral bias.

CONCLUSIONS CONCLUSIONS

Pediatric melanoma can be fatal in diverse clinical presentations, including a striking prevalence of Hispanic patients compared to adult disease, and with a range of clinical subtypes, although no fatal cases of spitzoid melanoma were diagnosed during childhood.

Identifiants

DOI: 10.1016/j.jaad.2020.06.1010 PMID: 32622142

pubmed: 32622142

pii: S0190-9622(20)32110-1

doi: 10.1016/j.jaad.2020.06.1010

pii:

doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

Pagination

1274-1281