Characterization of an i.p. D-galactose-induced cataract model in rats.
Cataract
D-galactose
Element of lens
Na(+)/K(+) ratio
Rat
Journal
Journal of pharmacological and toxicological methods
ISSN: 1873-488X
Titre abrégé: J Pharmacol Toxicol Methods
Pays: United States
ID NLM: 9206091
Informations de publication
Date de publication:
Historique:
received:
03
09
2019
revised:
15
06
2020
accepted:
16
06
2020
pubmed:
6
7
2020
medline:
26
11
2021
entrez:
6
7
2020
Statut:
ppublish
Résumé
Cataracts have been identified as a main cause of global visual impairment and blindness; in addition, diabetic and aging cataracts are the most common types. The aim of this project was to develop a suitable animal model and investigate the key points of the mechanisms by which intraperitoneal (i.p.) injection of D-galactose forms cataracts. We optimized a method to investigate the safest and effective method and dosage; rats in Group H were treated with 50% D-galactose 15 g/kg i.p. twice daily based on the 11 different treatment methods. The simple oral group showed considerable differences in the same observed time, while the i.p. group showed relatively uniform cataracts due to intake of the same dose of D-galactose. The data suggest that i.p. injection of galactose is a relatively more successful and stable cataract-inducing method with a low mortality rate. Based on this model, we found that Na
Identifiants
pubmed: 32622754
pii: S1056-8719(20)30220-3
doi: 10.1016/j.vascn.2020.106891
pii:
doi:
Substances chimiques
Sodium
9NEZ333N27
Galactose
X2RN3Q8DNE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106891Informations de copyright
Copyright © 2020. Published by Elsevier Inc.