Change of tear lipid mediators in a post-trabeculectomy cohort.

Glaucoma / surgery Humans Ophthalmic Solutions Sclera Tears Trabeculectomy
Cohort study Dry eye Glaucoma surgery Lipid mediators Mass spectrometry Ocular surface disease

Journal

The ocular surface
ISSN: 1937-5913
Titre abrégé: Ocul Surf
Pays: United States
ID NLM: 101156063

Informations de publication

Date de publication:
10 2020
Historique:
received: 21 10 2019
revised: 02 02 2020
accepted: 06 06 2020
pubmed: 6 7 2020
medline: 13 5 2021
entrez: 6 7 2020
Statut: ppublish

Résumé

Trabeculectomy surgery could affect ocular surface disease (OSD) in several ways, through cessation of long term glaucoma eyedrops, exposure to operative mitomycin C and post-operative eyedrops including corticosteroids and aminoglycosides and reduction in eyelid hygiene measures. Previously we showed the relevance of tear lipid mediators (also referred oxylipins) in OSD. Here, we aim to evaluate changes of these lipids in a post-trabeculectomy cohort. Patients undergoing trabeculectomy were prospectively evaluated and had tear collected using Schirmer's strips, preoperatively and postoperatively at 0.5, 1.0 and 3.0 years. Lipid mediators were analyzed using liquid chromatography mass spectrometry. The normalized concentrations of 40 lipid mediators were between 0.1 and 8.0 ng/mL, whereas docosahexaenoic acid (DHA), Arachidonic acid (AA) and eicosapentaenoic acid (EPA) ranged up to a few hundred ng/mL. The concentrations of lipid mediators, except DHA, EPA, and thromboxane (TXB An increase in the level of 2,3-dinor-8-isoPGF In this 3-years study, trabeculectomy reduced the tear level of pro-inflammatory lipid mediators. Patients who required needling of the bleb to maintain surgical success may have a chronic underlying inflammatory process associated with fibrosis.

Identifiants

DOI: 10.1016/j.jtos.2020.06.004 PMID: 32622916
pubmed: 32622916
pii: S1542-0124(20)30101-4
doi: 10.1016/j.jtos.2020.06.004
pii:
doi:

Substances chimiques

Ophthalmic Solutions 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

565-574

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Yohannes Abere Ambaw (YA)

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore; Department of Molecular Metabolism, Harvard T.H Chan School of Public Health, Harvard Univeristy, USA. Electronic address: e0010790@u.nus.edu.

Tina Wong (T)

Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Cornea and External Eye Disease, Singapore National Eye Center, Singapore; Ocular Surface Research Group, Singapore Eye Research Institute, Singapore; Eye-Academic Clinical Program, Duke-NUS Medical School, Singapore; School of Material Science and Engineering, Nanyang Technological University, Singapore. Electronic address: tina.wong.t.l@singhealth.com.sg.

Rachel Chong (R)

Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Glaucoma, Singapore National Eye Center, Singapore.

Hou Ah (H)

Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Ocular Surface Research Group, Singapore Eye Research Institute, Singapore.

Shanshan Ji (S)

Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore.

Manfred Raida (M)

Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore.

Federico Torta (F)

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore.

Markus R Wenk (MR)

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Louis Tong (L)

Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Cornea and External Eye Disease, Singapore National Eye Center, Singapore; Ocular Surface Research Group, Singapore Eye Research Institute, Singapore; Eye-Academic Clinical Program, Duke-NUS Medical School, Singapore. Electronic address: louis.tong.h.t@singhealth.com.sg.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'oeil › Hypertension oculaire › Glaucome › Change of tear lipid mediators in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Change of tear lipid mediators in a...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solutions pharmaceutiques › Solutions ophtalmiques › Change of tear lipid mediators in a...
questionsmedicales.fr › Organes des sens › Oeil › Sclère › Change of tear lipid mediators in a...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Larmes › Change of tear lipid mediators in a...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie ophtalmologique › Chirurgie filtrante › Trabéculectomie › Change of tear lipid mediators in a...