Mesenchymal stromal cells and their secreted extracellular vesicles as therapeutic tools for COVID-19 pneumonia?
Journal
Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908
Informations de publication
Date de publication:
10 09 2020
10 09 2020
Historique:
received:
21
04
2020
revised:
12
06
2020
accepted:
29
06
2020
pubmed:
6
7
2020
medline:
28
8
2020
entrez:
6
7
2020
Statut:
ppublish
Résumé
The COVID-19 epidemic represents an unprecedented global health emergency, further aggravated by the lack of effective therapies. For this reason, several clinical trials are testing different off-label drugs, already approved for other pathologies. Mesenchymal stem/stromal cells (MSCs) have been tested during the last two decades for the treatment of various pathologic conditions, including acute and chronic lung diseases, both in animal models and in patients. In particular, promising results have been obtained in the experimental therapy of acute respiratory distress syndrome, which represents the most threatening complication of COVID-19 infection. Furthermore, more recently, great interest has been devoted to the possible clinical applications of extracellular vesicles secreted by MSCs, nanoparticles that convey much of the biological effects and of the therapeutic efficacy of their cells of origin. This review summarizes the experimental evidence underlying the possible use of MSCs and of MSC-EVs in severe COVID-19 infection and underlines the need to evaluate the possible efficacy of these therapeutic approaches through controlled studies under the supervision of the Regulatory Authorities.
Identifiants
pubmed: 32622963
pii: S0168-3659(20)30371-0
doi: 10.1016/j.jconrel.2020.06.036
pmc: PMC7332437
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-140Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
Références
J Transl Med. 2005 Feb 21;3(1):9
pubmed: 15723705
Stem Cells. 2017 Apr;35(4):851-858
pubmed: 28294454
Am J Respir Crit Care Med. 2010 Oct 15;182(8):1047-57
pubmed: 20558630
Front Immunol. 2017 Jul 31;8:881
pubmed: 28824619
Am J Respir Crit Care Med. 2017 Aug 1;196(3):266-273
pubmed: 28306336
Nat Med. 2009 Jan;15(1):42-9
pubmed: 19098906
Med Res Rev. 2014 Sep;34(5):1100-26
pubmed: 24866817
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Crit Care Med. 2010 Oct;38(10 Suppl):S569-73
pubmed: 21164399
Stem Cell Res Ther. 2018 Jan 29;9(1):17
pubmed: 29378639
Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L6-L19
pubmed: 30284924
Curr Pharm Des. 2013;19(13):2459-73
pubmed: 23278600
Thorax. 2017 Jan;72(1):1-3
pubmed: 27974631
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
J Intern Med. 2007 Nov;262(5):509-25
pubmed: 17949362
Best Pract Res Clin Haematol. 2011 Mar;24(1):65-72
pubmed: 21396594
EClinicalMedicine. 2020 Jan 17;19:100249
pubmed: 31989101
Int Wound J. 2014 Apr;11(2):114-21
pubmed: 24373614
JCI Insight. 2019 Nov 1;4(21):
pubmed: 31581150
Bone Res. 2020 Feb 14;8:8
pubmed: 32128276
Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):148-156
pubmed: 26928656
Am J Respir Crit Care Med. 2018 Jan 1;197(1):104-116
pubmed: 28853608
Cell Transplant. 2017 Apr 13;26(4):531-539
pubmed: 27938500
Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S54-7
pubmed: 25830837
Cell Death Dis. 2016 Jan 21;7:e2062
pubmed: 26794657
Leukemia. 2014 Apr;28(4):970-3
pubmed: 24445866
Crit Care Clin. 2011 Jul;27(3):719-33
pubmed: 21742225
Epidemiol Health. 2020;42:e2020013
pubmed: 32192278
Chin Med J (Engl). 2012 Dec;125(23):4296-300
pubmed: 23217403
Thorax. 2019 Jan;74(1):43-50
pubmed: 30076187
Biotechnol Adv. 2018 Dec;36(8):2051-2059
pubmed: 30218694
Nat Med. 2005 Aug;11(8):821-2
pubmed: 16079870
Stem Cells. 2017 Apr;35(4):1093-1105
pubmed: 28164431
Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737):
pubmed: 29158309
Respirology. 2016 Nov;21(8):1366-1375
pubmed: 27688156
Stem Cells Dev. 2020 Jun 15;29(12):747-754
pubmed: 32380908
Intensive Care Med. 2020 Apr;46(4):586-590
pubmed: 32125455
Stem Cells. 2010 Dec;28(12):2229-38
pubmed: 20945332
J Tissue Eng Regen Med. 2019 Sep;13(9):1738-1755
pubmed: 31216380
Curr Opin Cell Biol. 2014 Aug;29:116-25
pubmed: 24959705
J Virol. 2011 May;85(9):4122-34
pubmed: 21325420
Am J Respir Crit Care Med. 2018 Apr 1;197(7):969-970
pubmed: 29160724
Int J Mol Sci. 2017 May 09;18(5):
pubmed: 28486410
Ann Intern Med. 2020 Aug 18;173(4):268-277
pubmed: 32374815
J Pathol. 2004 Jun;203(2):631-7
pubmed: 15141377
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16357-62
pubmed: 19721001
Aging Dis. 2020 Mar 9;11(2):216-228
pubmed: 32257537
Cell Transplant. 2009;18(4):405-22
pubmed: 19622228
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Am J Transplant. 2015 Sep;15(9):2404-12
pubmed: 25847030
Biochem Biophys Res Commun. 2018 Sep 18;503(4):2653-2658
pubmed: 30093115
Stem Cells Transl Med. 2015 Oct;4(10):1199-213
pubmed: 26285659
Biochim Biophys Acta. 2012 Jul;1820(7):940-8
pubmed: 22503788
Am J Transl Res. 2018 Aug 15;10(8):2628-2635
pubmed: 30210699
Cell Transplant. 2013;22(2):369-79
pubmed: 23433427
Mol Ther. 2016 Aug;24(7):1290-301
pubmed: 27203438
Cell Transplant. 2015;24(2):133-49
pubmed: 24268069
Chest. 2020 May;157(5):1175-1187
pubmed: 31730835
Am J Respir Crit Care Med. 2020 Oct 1;202(7):1051-1055
pubmed: 32501728
Cell Transplant. 2015;24(12):2615-27
pubmed: 25695896
Cell Stem Cell. 2009 Jul 2;5(1):54-63
pubmed: 19570514
Sci Rep. 2016 Apr 13;6:24120
pubmed: 27071676
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E968-77
pubmed: 26858453
J Bone Miner Res. 2018 Mar;33(3):517-533
pubmed: 29091316
Circ Res. 2008 Nov 21;103(11):1204-19
pubmed: 19028920
Clin Transl Med. 2019 Sep 12;8(1):25
pubmed: 31512000
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Turk J Med Sci. 2020 Apr 17;50(SI-1):620-632
pubmed: 32299202
Front Immunol. 2011 Nov 24;2:65
pubmed: 22566854
Lancet Respir Med. 2019 Feb;7(2):154-162
pubmed: 30455077
NPJ Regen Med. 2019 Dec 2;4:22
pubmed: 31815001
Tissue Eng Part B Rev. 2012 Apr;18(2):101-15
pubmed: 21995703
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Ann Transl Med. 2020 Mar;8(6):334
pubmed: 32355778
Am J Respir Crit Care Med. 2015 Aug 1;192(3):324-36
pubmed: 26067592
Nat Med. 2005 Aug;11(8):875-9
pubmed: 16007097
J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):880-897
pubmed: 30230266
Eur J Vasc Endovasc Surg. 2019 Apr;57(4):538-545
pubmed: 30686676
Am J Respir Crit Care Med. 2018 Feb 1;197(3):337-347
pubmed: 28960096
Biomaterials. 2011 Nov;32(32):8139-49
pubmed: 21840589
J Control Release. 2014 Oct 28;192:262-70
pubmed: 25084218
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Sci Transl Med. 2019 May 15;11(492):
pubmed: 31092696
Br J Clin Pharmacol. 2020 Mar 10;:
pubmed: 32154598
J Control Release. 2014 Dec 10;195:72-85
pubmed: 25094032
Cells. 2020 Apr 16;9(4):
pubmed: 32316248
Cells. 2019 Mar 19;8(3):
pubmed: 30893822
Transfusion. 2019 Feb;59(S1):876-883
pubmed: 30383895
J Virol. 2010 Jan;84(2):1198-205
pubmed: 19864379
ACS Nano. 2017 Jan 24;11(1):69-83
pubmed: 28068069
Br J Pharmacol. 2012 Jul;166(6):1964-76
pubmed: 22339213