Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across Permeapad
Drug permeability
Dynamic permeation model
In vivo pharmacokinetics
Steady-state flux
Supersaturated lipid-based drug delivery systems
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982
Informations de publication
Date de publication:
01 Sep 2020
01 Sep 2020
Historique:
received:
03
06
2020
revised:
01
07
2020
accepted:
01
07
2020
pubmed:
6
7
2020
medline:
22
6
2021
entrez:
6
7
2020
Statut:
ppublish
Résumé
Supersaturated lipid-based drug delivery systems have recently been investigated for oral administration for a variety of lipophilic drugs and have shown either equivalent or superior oral bioavailability compared to conventional non-supersaturated lipid-based drug delivery systems. The aim of the present work was to explore supersaturated versus non-supersaturated lipid-based systems at equivalent lipid doses, on in vivo bioavailability in rats and on in vitro permeation across a biomimetic Permeapad
Identifiants
pubmed: 32622980
pii: S0928-0987(20)30241-4
doi: 10.1016/j.ejps.2020.105452
pii:
doi:
Substances chimiques
Lipids
0
Celecoxib
JCX84Q7J1L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105452Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.