Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus with Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia.
Amyloid-β
apolipoprotein E
plasminogen activator
positron emission tomography
type 2 diabetes
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
6
7
2020
medline:
4
6
2021
entrez:
6
7
2020
Statut:
ppublish
Résumé
We explored the association of type 2 diabetes related blood markers with brain amyloid accumulation on PiB-PET scans in 41 participants from the FINGER PET sub-study. We built logistic regression models for brain amyloid status with12 plasma markers of glucose and lipid metabolism, controlled for diabetes and APOEɛ4 carrier status. Lower levels of insulin, insulin resistance index (HOMA-IR), C-peptide, and plasminogen activator (PAI-1) were associated with amyloid positive status, although the results were not significant after adjusting for multiple testing. None of the models found evidence for associations between amyloid status and fasting glucose or HbA1c.
Identifiants
pubmed: 32623394
pii: JAD200145
doi: 10.3233/JAD-200145
pmc: PMC7504982
doi:
Substances chimiques
Amyloid
0
Apolipoprotein E4
0
Biomarkers
0
Insulin
0
Types de publication
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1243-1248Références
Sci Rep. 2017 Aug 29;7(1):9766
pubmed: 28852028
JAMA Neurol. 2013 Sep 1;70(9):1167-72
pubmed: 23897112
JAMA. 2000 Jan 12;283(2):221-8
pubmed: 10634338
Alzheimers Dement (Amst). 2015 Sep 1;1(3):339-348
pubmed: 26693175
Neurology. 2018 Mar 27;90(13):e1150-e1157
pubmed: 29476033
Lancet Neurol. 2006 Sep;5(9):735-41
pubmed: 16914401
Alzheimers Res Ther. 2017 Apr 26;9(1):31
pubmed: 28441961
Neurology. 2010 Sep 28;75(13):1195-202
pubmed: 20739645
Alzheimers Dement. 2016 Aug;12(8):882-9
pubmed: 26812281
Intern Med J. 2012 May;42(5):484-91
pubmed: 22372522
Alzheimers Dement. 2015 May;11(5):504-510.e1
pubmed: 25043908
J Alzheimers Dis. 2017;59(2):695-705
pubmed: 28671114
Lancet. 2015 Jun 6;385(9984):2255-63
pubmed: 25771249
Int J Neurosci. 2013 Jan;123(1):42-9
pubmed: 22937735
Neurology. 2018 Jan 16;90(3):e206-e213
pubmed: 29263220
J Neural Transm (Vienna). 2012 Jul;119(7):763-9
pubmed: 22415062
Neurobiol Aging. 2012 May;33(5):1003.e9-17
pubmed: 22014619
Neuropathol Appl Neurobiol. 2018 Jun;44(4):347-362
pubmed: 29424027
Brain Res. 2015 Feb 9;1597:159-67
pubmed: 25454795
Drugs. 2017 Jan;77(1):47-65
pubmed: 27988872