Decreased interhemispheric resting-state functional connectivity in male adolescents with conduct disorder.
Conduct disorder
Interhemispheric coordination
Resting-state functional magnetic resonance imaging
Voxel-mirrored homotopic connectivity
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
pubmed:
6
7
2020
medline:
21
7
2021
entrez:
6
7
2020
Statut:
ppublish
Résumé
Conduct disorder (CD) is a common psychiatric disorder defined by a repetitive and persistent pattern of aggressive and antisocial behaviors. Although numerous task-based and resting-state functional magnetic resonance imaging (rsfMRI) studies have emphasized the disrupted functional connectivity in CD, the CD-related alterations in functional interactions between the bilateral cerebral hemispheres are rarely investigated directly. In this study, a voxel-mirrored homotopic connectivity (VMHC) method based on rsfMRI was employed for the first time to examine the abnormalities of interhemispheric functional connectivity in patients with CD. The VMHC was compared between eighteen pure CD patients and eighteen typically developing (TD) healthy controls. In CD patients, reduced homotopic connectivity was observed relative to TDs in the middle occipital gyrus (MOG), pre- and postcentral gyrus, rolandic operculum and paracentral lobe (PCL) which were the components of visual and motor networks. Furthermore, the VMHC of the MOG and PCL was found to be negatively correlated with clinical scores in the CD group. Moreover, the regions with altered VMHC exhibited a relative good and robust ability to discriminate CD patients from TDs. This study provided a novel angle to identify the important role of interhemispheric coordination in the pathophysiology underlying CD and further indicated that the aberrant homotopic connectivity could be a potential clinical neural marker for CD diagnosis.
Identifiants
pubmed: 32623563
doi: 10.1007/s11682-020-00320-8
pii: 10.1007/s11682-020-00320-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1201-1210Subventions
Organisme : National Natural Science Foundation of China
ID : 81571341
Organisme : National Natural Science Foundation of China
ID : 61876114
Organisme : National Natural Science Foundation of China
ID : 61901129
Organisme : grant from the University of Macau
ID : MYRG2018-00081-FHS
Organisme : grant from the Macao government
ID : FDCT 0011/2018/A1
Organisme : National Natural Science Foundation of China
ID : 31800961
Organisme : National Natural Science Foundation of China
ID : 81603673
Organisme : Sichuan Science and Technology Program
ID : 2018JY0361
Organisme : Sichuan Science and Technology Program
ID : 2017JY0031
Organisme : China Postdoctoral Science Foundation Grant
ID : 2018M633336
Organisme : China Postdoctoral Science Foundation Grant
ID : 2019M653383
Organisme : China Postdoctoral Science Foundation Grant
ID : 2019M660236
Organisme : Cangzhou science and technology research and development project
ID : 162302137
Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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