Cell-based assays for the detection of MOG antibodies: a comparative study.

Autoantibodies Humans Immunoglobulin G Multiple Sclerosis / diagnosis Myelin-Oligodendrocyte Glycoprotein Syndrome
Autoantibodies Cell-based assay Demyelinating disorders Multiple sclerosis Myelin oligodendrocyte glycoprotein Myelitis Optic neuritis Standardization

Journal

Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 02 05 2020
accepted: 25 06 2020
revised: 23 06 2020
pubmed: 6 7 2020
medline: 22 6 2021
entrez: 6 7 2020
Statut: ppublish

Résumé

The detection of antibodies to myelin oligodendrocyte glycoprotein (MOG) is fundamental for the identification of MOG antibody-associated disorders (MOGAD), and the differential diagnosis of acquired demyelinating syndromes of the CNS, among which multiple sclerosis (MS). We compared the diagnostic performance of four cell-based assays (CBAs) for their detection. Consecutive sera from 204 patients with 'possible MOGAD' (55), MS (112), and other neurological disorders (OND, 37) were tested for MOG-IgG with a live-CBA with anti-heavy-and-light chain secondary-antibody (LCBA-IgG LCBA-IgG

Sections du résumé

BACKGROUND BACKGROUND
The detection of antibodies to myelin oligodendrocyte glycoprotein (MOG) is fundamental for the identification of MOG antibody-associated disorders (MOGAD), and the differential diagnosis of acquired demyelinating syndromes of the CNS, among which multiple sclerosis (MS). We compared the diagnostic performance of four cell-based assays (CBAs) for their detection.
METHODS METHODS
Consecutive sera from 204 patients with 'possible MOGAD' (55), MS (112), and other neurological disorders (OND, 37) were tested for MOG-IgG with a live-CBA with anti-heavy-and-light chain secondary-antibody (LCBA-IgG
CONCLUSIONS CONCLUSIONS
LCBA-IgG

Identifiants

DOI: 10.1007/s00415-020-10024-0 PMID: 32623596
pubmed: 32623596
doi: 10.1007/s00415-020-10024-0
pii: 10.1007/s00415-020-10024-0
doi:

Substances chimiques

Autoantibodies 0
Immunoglobulin G 0
Myelin-Oligodendrocyte Glycoprotein 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3555-3564

Subventions

Organisme : Ministero della Salute
ID : RC1812C

Auteurs

Matteo Gastaldi (M)

Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy. matteo.gastaldi@mondino.it.
Neuro-Oncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia, Italy. matteo.gastaldi@mondino.it.
ORCID: 0000-0003-2288-2000

Silvia Scaranzin (S)

Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.

Sven Jarius (S)

Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Otto Meyerhof Center, Heidelberg, Germany.

Brigitte Wildeman (B)

Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Otto Meyerhof Center, Heidelberg, Germany.

Elisabetta Zardini (E)

Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.

Giulia Mallucci (G)

Multiple Sclerosis Centre, IRCCS Mondino Foundation, Pavia, Italy.

Eleonora Rigoni (E)

Multiple Sclerosis Centre, IRCCS Mondino Foundation, Pavia, Italy.

Elisa Vegezzi (E)

Neuro-Oncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia, Italy.

Thomas Foiadelli (T)

Pediatric Clinic, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Salvatore Savasta (S)

Pediatric Clinic, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Paola Banfi (P)

Neurology and Stroke Unit, Circolo Hospital/Macchi Foundation, University of Insubria, Varese, Italy.

Maurizio Versino (M)

Neurology and Stroke Unit, Circolo Hospital/Macchi Foundation, University of Insubria, Varese, Italy.

Luana Benedetti (L)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.

Giovanni Novi (G)

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
IRCCS Policlinico San Martino, Genoa, Italy.

Margherita Maria Mancardi (MM)

Unit of Child Neuropsychiatry, Clinical and Surgical Neurosciences Department, IRCCS Istituto Giannina Gaslini, Genova, Italy.

Thea Giacomini (T)

Unit of Child Neuropsychiatry, Clinical and Surgical Neurosciences Department, IRCCS Istituto Giannina Gaslini, Genova, Italy.

Pietro Annovazzi (P)

Multiple Sclerosis Centre, ASST Valle Olona - Gallarate Hospital, Gallarate, Italy.

Damiano Baroncini (D)

Multiple Sclerosis Centre, ASST Valle Olona - Gallarate Hospital, Gallarate, Italy.

Diana Ferraro (D)

Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Modena, Italy.

Vito Lampasona (V)

San Raffaele Diabetes Research Institute, IRCCS San Raffaele Hospital, Milan, Italy.

Markus Reindl (M)

Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

Patrick Waters (P)

Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

Diego Franciotta (D)

Neuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Cell-based assays for the detection of MOG...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cell-based assays for the detection of MOG...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Cell-based assays for the detection of MOG...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Cell-based assays for the detection of MOG...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Glycoprotéine MOG › Cell-based assays for the detection of MOG...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Maladie › Syndrome › Cell-based assays for the detection of MOG...