Versican and Versican-matrikines in Cancer Progression, Inflammation, and Immunity.
biomarkers
dendritic cells
extracellular matrix
glycosaminoglycan
immunotherapy
macrophages
matrikines
myeloid cells
proteoglycan
versican
versikine
Journal
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
ISSN: 1551-5044
Titre abrégé: J Histochem Cytochem
Pays: United States
ID NLM: 9815334
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
7
7
2020
medline:
20
1
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer development, ranging from proliferative signaling, evasion of growth-suppressor pathways, regulation of cell death, promotion of neoangiogenesis, and tissue invasion and metastasis. Multiple lines of evidence implicate versican and its bioactive proteolytic fragments (matrikines) in the regulation of cancer inflammation and antitumor immune responses. The understanding of the dynamics of versican deposition/accumulation and its proteolytic turnover holds potential for the development of novel immune biomarkers as well as approaches to reset the immune thermostat of tumors, thus promoting efficacy of modern immunotherapies. This article summarizes work from several laboratories, including ours, on the role of this central matrix proteoglycan in tumor progression as well as tumor-immune cell cross-talk.
Identifiants
pubmed: 32623942
doi: 10.1369/0022155420937098
pmc: PMC7711242
doi:
Substances chimiques
Extracellular Matrix Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
871-885Subventions
Organisme : NCI NIH HHS
ID : R01 CA252937
Pays : United States
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