Hyponatraemia and cerebral oedema due to a modafinil overdose.
coma and raised intracranial pressure
drug misuse (including addiction)
drugs: CNS (not psychiatric)
poisoning
unwanted effects / adverse reactions
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
05 Jul 2020
05 Jul 2020
Historique:
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Modafinil is a non-amphetamine stimulant that is prescribed for narcolepsy-associated sleepiness as well as reported off-licence uses among university students looking to improve wakefulness and focus. There is limited information in the medical literature about supratherapeutic modafinil dosage, symptomatology and management of overdose. We report a case of a healthy 32-year-old man who was found unconscious, having vomited, with an empty modafinil blister strip. At the emergency department, he presented with reduced Glasgow Coma Scale and prolonged episodes of vomiting. This acute presentation was conservatively managed in the intensive care unit. Antibiotics were also given for a suspected aspiration pneumonia. CT of the head showed cerebral oedema and biochemistry investigations revealed hyponatraemia. Result aetiology was unclear, however, it has been theorised to be secondary to a sizeable modafinil overdose.
Identifiants
pubmed: 32624486
pii: 13/7/e234530
doi: 10.1136/bcr-2020-234530
pmc: PMC7337617
pii:
doi:
Substances chimiques
Central Nervous System Stimulants
0
Modafinil
R3UK8X3U3D
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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