Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort.
breast cancer
polygenic risk score
prospective cohort
risk assessment
Journal
Genetics in medicine : official journal of the American College of Medical Genetics
ISSN: 1530-0366
Titre abrégé: Genet Med
Pays: United States
ID NLM: 9815831
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
24
03
2020
accepted:
16
06
2020
revised:
08
06
2020
pubmed:
7
7
2020
medline:
29
4
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
We evaluated the performance of the recently extended Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch prospective cohort, using a polygenic risk score (PRS) based on 313 breast cancer (BC)-associated variants (PRS Since 1989, 6522 women without BC aged 45 or older of European descent have been included in the Rotterdam Study. The PRS In total, 320 women developed BC. The PRS The effect size of the PRS
Identifiants
pubmed: 32624571
doi: 10.1038/s41436-020-0884-4
pii: S1098-3600(21)00775-9
pmc: PMC7605432
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1803-1811Références
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