Quantitative genome-wide association study of six phenotypic subdomains identifies novel genome-wide significant variants in autism spectrum disorder.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
05 07 2020
05 07 2020
Historique:
received:
28
10
2019
accepted:
26
05
2020
revised:
17
05
2020
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Autism spectrum disorders (ASD) are highly heritable and are characterized by deficits in social communication and restricted and repetitive behaviors. Twin studies on phenotypic subdomains suggest a differing underlying genetic etiology. Studying genetic variation explaining phenotypic variance will help to identify specific underlying pathomechanisms. We investigated the effect of common variation on ASD subdomains in two cohorts including >2500 individuals. Based on the Autism Diagnostic Interview-Revised (ADI-R), we identified and confirmed six subdomains with a SNP-based genetic heritability h
Identifiants
pubmed: 32624584
doi: 10.1038/s41398-020-00906-2
pii: 10.1038/s41398-020-00906-2
pmc: PMC7335742
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
215Subventions
Organisme : Universität des Saarlandes (Saarland University)
ID : T6 03 10 00 - 45
Pays : International
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