Red cell distribution width as a marker of activity in inflammatory bowel disease: a narrative review.

Crohn’s disease Red cell distribution width disease activity inflammatory bowel disease ulcerative colitis

Journal

Annals of gastroenterology
ISSN: 1108-7471
Titre abrégé: Ann Gastroenterol
Pays: Greece
ID NLM: 101121847

Informations de publication

Date de publication:
Historique:
received: 01 02 2020
accepted: 08 03 2020
entrez: 7 7 2020
pubmed: 7 7 2020
medline: 7 7 2020
Statut: ppublish

Résumé

Red blood cell distribution width is a parameter measured automatically in every complete blood count that actually reflects the degree of anisocytosis of the red blood cell population. It is a cost-effective tool used in everyday clinical practice along with other parameters to define and narrow the cause of anemia. In a series of pathologic entities, such as cardiovascular diseases, autoimmune diseases, malignancy, chronic renal diseases and chronic respiratory diseases, where inflammation and oxidative stress comprise the major pathophysiologic insults, red cell distribution width behaves as a significant and competent marker able to predict and assess disease activity and severity. A number of clinical studies based on these observations have aimed to evaluate its potential utility as an index of activity in inflammatory bowel disease. In this narrative review we present data from the international literature regarding its ability to express disease activity and we look into its relation with clinical, laboratory and endoscopic indices used to identify active disease. According to the results of published clinical trials, red cell distribution width is considerably correlated with disease activity and might serve as an index to differentiate Crohn's disease from ulcerative colitis.

Identifiants

pubmed: 32624654
doi: 10.20524/aog.2020.0486
pii: AnnGastroenterol-33-348
pmc: PMC7315702
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

348-354

Informations de copyright

Copyright: © Hellenic Society of Gastroenterology.

Déclaration de conflit d'intérêts

Conflict of Interest: None

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Auteurs

Marios Katsaros (M)

Gastroenterology and Hepatology Division of the Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital (Marios Katsaros, Olga Giouleme).

Paschalis Paschos (P)

First Department of Internal Medicine, "Papageorgiou" Hospital (Paschalis Paschos), Thessaloniki, Greece.

Olga Giouleme (O)

Gastroenterology and Hepatology Division of the Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital (Marios Katsaros, Olga Giouleme).

Classifications MeSH