Production of polycaprolactone nanoparticles with hydrodynamic diameters below 100 nm.
aptamer
nanoparticle
paclitaxel
polycaprolactone
Journal
Engineering in life sciences
ISSN: 1618-0240
Titre abrégé: Eng Life Sci
Pays: Germany
ID NLM: 101193313
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
30
12
2018
revised:
27
06
2019
accepted:
31
07
2019
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
7
7
2020
Statut:
epublish
Résumé
Cancer is a worldwide increasing burden and its therapy is often challenging and causes severe side effects in healthy tissue. If drugs are loaded into nanoparticles, side effects can be reduced, and efficiency can be increased via the enhanced permeability and retention effect. This effect is based on the fact that nanoparticles with sizes from 10 to 200 nm can accumulate in tumor tissue due to their leaky vasculature. In this work, we produced polycaprolactone (PCL) in the sizes 1.8, 5.4, and 13.6 kDa and were able to produce spherical shaped nanoparticles with mean diameters of 64 ± 19 nm out of the PCL
Identifiants
pubmed: 32624959
doi: 10.1002/elsc.201800214
pii: ELSC1245
pmc: PMC6999587
doi:
Types de publication
Journal Article
Langues
eng
Pagination
658-665Informations de copyright
© 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.
Déclaration de conflit d'intérêts
The authors have declared no conflict of interest. The manuscript does not contain experiments using animals or human studies.
Références
Colloids Surf B Biointerfaces. 2010 Jan 1;75(1):1-18
pubmed: 19782542
Oncotarget. 2018 Apr 20;9(30):20993-21006
pubmed: 29765515
Bioconjug Chem. 2001 Nov-Dec;12(6):917-23
pubmed: 11716682
Science. 1990 Aug 3;249(4968):505-10
pubmed: 2200121
Biochem J. 2004 Jan 1;377(Pt 1):159-69
pubmed: 14505488
ACS Nano. 2009 Jan 27;3(1):16-20
pubmed: 19206243
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Chemistry. 2016 Jul 11;22(29):9886-900
pubmed: 27243551
ACS Biomater Sci Eng. 2019 Feb 11;5(2):683-695
pubmed: 33405831
Biomaterials. 2001 Jul;22(13):1697-704
pubmed: 11396872
Colloids Surf B Biointerfaces. 2015 Dec 1;136:355-64
pubmed: 26433348
Drug Deliv Transl Res. 2018 Dec;8(6):1790-1796
pubmed: 28828703
Handb Exp Pharmacol. 2010;(197):3-53
pubmed: 20217525
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
pubmed: 21296855
Bioanalysis. 2010 May;2(5):907-18
pubmed: 20657791
J Colloid Interface Sci. 2012 Dec 1;387(1):180-6
pubmed: 22939528
Pharm Res. 2017 Sep;34(9):1773-1783
pubmed: 28527126
J Pharm Sci. 2008 Mar;97(3):1179-90
pubmed: 17683080
Nanoscale Res Lett. 2009 Sep 16;4(12):1530-9
pubmed: 20652101
Eng Life Sci. 2019 Aug 12;19(10):658-665
pubmed: 32624959