Specific N-demethylation of verapamil by cytochrome P450 from
N‐demethylation
biocatalysis
cytochrome P450
norverapamil
verapamil
Journal
Engineering in life sciences
ISSN: 1618-0240
Titre abrégé: Eng Life Sci
Pays: Germany
ID NLM: 101193313
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
17
07
2018
revised:
07
01
2019
accepted:
13
02
2019
entrez:
7
7
2020
pubmed:
25
2
2019
medline:
25
2
2019
Statut:
epublish
Résumé
Norverapamil, the N-demethylated derivative of verapamil, is a novel promising leading compound for attenuating multidrug resistance with less side effects compared with verapamil. However, the efficient synthetic method for norverapamil is absent. In this study, an innovative biotechnological method based on enzymatic catalysis was presented for the high-efficient production of norverapamil. CYP105D1, a cytochrome P450 from
Identifiants
pubmed: 32625009
doi: 10.1002/elsc.201800116
pii: ELSC1198
pmc: PMC6999465
doi:
Types de publication
Journal Article
Langues
eng
Pagination
292-301Informations de copyright
© 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.
Déclaration de conflit d'intérêts
The authors have declared no conflict of interest.
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