Cyclophilin D: An Integrator of Mitochondrial Function.

ATP synthase cyclophilin D cyclosporine A mitochondrial function peptidyl-prolyl cis-trans isomerase permeability transition pore

Journal

Frontiers in physiology

ISSN: 1664-042X

Titre abrégé: Front Physiol

Pays: Switzerland

ID NLM: 101549006

Informations de publication

Date de publication:
2020

Historique:

received: 06 03 2020

accepted: 13 05 2020

entrez: 7 7 2020

pubmed: 7 7 2020

medline: 7 7 2020

Statut: epublish

Résumé

Cyclophilin D (CypD) is a mitochondrial peptidyl-prolyl cis-trans isomerase, well-known for regulating the mitochondrial permeability transition pore (PTP), a nonspecific large conductance pore whose opening leads to cell death and has been implicated in ischemia/reperfusion injury in multiple organs, in neurodegenerative disorders, and in muscular dystrophies. While the main target of CypD is a matter of ongoing research, inhibiting CypD protects in models of those diseases making it an interesting therapeutic target. The present review focuses on post-translational modifications of CypD that have been identified by recent studies, which can alter the regulation of the PTP and contribute to understanding the mechanisms of action of CypD.

Identifiants

DOI: 10.3389/fphys.2020.00595 PMID: 32625108 PMC: PMC7311779

pubmed: 32625108

doi: 10.3389/fphys.2020.00595

pmc: PMC7311779

doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

595

Informations de copyright

Références

Neuron. 2017 Feb 8;93(3):587-605.e7

pubmed: 28132831

J Alzheimers Dis. 2017;55(4):1351-1362

pubmed: 27834780

Cardiovasc Res. 2002 Aug 15;55(3):534-43

pubmed: 12160950

Circ Res. 2002 Mar 8;90(4):377-9

pubmed: 11884365

Cardiovasc Res. 2020 Mar 04;:

pubmed: 32129829

Biochem Biophys Res Commun. 2011 Jul 15;410(4):916-21

pubmed: 21708132

Arch Biochem Biophys. 2009 Nov;491(1-2):39-45

pubmed: 19735641

Circ Res. 2000 Aug 18;87(4):309-15

pubmed: 10948065

Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1311-F1317

pubmed: 31339772

Nature. 2005 Mar 31;434(7033):652-8

pubmed: 15800626

Basic Res Cardiol. 2017 Jul;112(4):35

pubmed: 28492973

Cardiovasc Res. 1998 Jun;38(3):676-84

pubmed: 9747435

J Biol Chem. 2008 Sep 26;283(39):26312-23

pubmed: 18667415

Circ Res. 2016 Mar 4;118(5):834-41

pubmed: 26712344

Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1327-35

pubmed: 21278135

J Natl Cancer Inst. 2015 Feb 03;107(3):

pubmed: 25650317

Circ Res. 2020 Jan 17;126(2):280-293

pubmed: 31944918

ACS Chem Biol. 2015 Jan 16;10(1):122-8

pubmed: 25555129

J Mol Cell Cardiol. 2013 Mar;56:81-90

pubmed: 23262437

FASEB J. 2015 Jul;29(7):2734-48

pubmed: 25837584

Cell Calcium. 2012 Jul;52(1):22-7

pubmed: 22513364

Am J Physiol Renal Physiol. 2011 Jul;301(1):F134-50

pubmed: 21490135

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):726-31

pubmed: 20080742

Nature. 2005 Mar 31;434(7033):658-62

pubmed: 15800627

Sci Rep. 2015 Oct 30;5:15981

pubmed: 26515038

Cardiovasc Res. 2019 Mar 1;115(3):625-636

pubmed: 30165375

Sci Adv. 2019 Aug 28;5(8):eaaw4597

pubmed: 31489369

Biochemistry. 2012 Apr 10;51(14):2959-73

pubmed: 22443365

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12005-10

pubmed: 16103352

Circ Res. 2011 Feb 18;108(4):418-26

pubmed: 21193739

Cardiovasc Res. 2019 Feb 1;115(2):385-394

pubmed: 30165576

Front Cardiovasc Med. 2018 Jun 06;5:68

pubmed: 29928647

Eur J Clin Invest. 2018 Jun;48(6):e12932

pubmed: 29603199

Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165674

pubmed: 31926263

Circ Res. 2013 Dec 6;113(12):1308-19

pubmed: 24062335

Cell Metab. 2017 Apr 4;25(4):765-776

pubmed: 28380371

Neurobiol Dis. 2002 Aug;10(3):219-33

pubmed: 12270685

Cell Calcium. 2012 Jul;52(1):28-35

pubmed: 22502861

J Am Coll Cardiol. 2016 Feb 2;67(4):365-374

pubmed: 26821623

PLoS Biol. 2010 Jul 27;8(7):e1000439

pubmed: 20676357

J Mol Cell Cardiol. 2015 Jul;84:61-9

pubmed: 25871830

J Cell Mol Med. 2020 Mar;24(5):2717-2729

pubmed: 31967733

J Biol Chem. 1996 Jan 26;271(4):2185-92

pubmed: 8567677

Proc Natl Acad Sci U S A. 1983 Aug;80(15):4732-6

pubmed: 6576355

Biophys J. 1999 Feb;76(2):725-34

pubmed: 9929477

Sci Rep. 2017 Jul 5;7(1):4683

pubmed: 28680068

J Biol Chem. 2011 Nov 18;286(46):40184-92

pubmed: 21930693

Cardiovasc Res. 2007 Aug 1;75(3):530-5

pubmed: 17512507

Nature. 2004 Jan 29;427(6973):461-5

pubmed: 14749836

J Cell Mol Med. 2011 Nov;15(11):2443-51

pubmed: 21143389

Aging (Albany NY). 2010 Dec;2(12):914-23

pubmed: 21212461

Mol Cell Biochem. 1997 Sep;174(1-2):181-4

pubmed: 9309684

J Biol Chem. 2009 Dec 4;284(49):33982-8

pubmed: 19801635

Circ Res. 2017 Apr 28;120(9):1477-1486

pubmed: 28450365

J Mol Cell Cardiol. 2005 Feb;38(2):367-74

pubmed: 15698843

J Biol Chem. 2013 Feb 22;288(8):5553-61

pubmed: 23303179

J Biol Chem. 1992 Jul 5;267(19):13115-8

pubmed: 1618811

Sci Rep. 2017 Nov 3;7(1):14488

pubmed: 29101324

N Engl J Med. 2015 Sep 10;373(11):1021-31

pubmed: 26321103

Am J Physiol Renal Physiol. 2009 Sep;297(3):F749-59

pubmed: 19553348

J Clin Invest. 2010 Oct;120(10):3680-7

pubmed: 20890047

EMBO J. 2015 Nov 3;34(21):2620-32

pubmed: 26358839

J Biol Chem. 2016 Feb 26;291(9):4356-73

pubmed: 26679998

EMBO Rep. 2017 Jul;18(7):1077-1089

pubmed: 28566520

Biochim Biophys Acta. 2014 Apr;1837(4):444-50

pubmed: 24368156