Healing Mechanism of Ruptured Fetal Membrane.
amnion
fetal membrane
macrophage
premature rupture of membrane
wound healing
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
02
2020
accepted:
18
05
2020
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
7
7
2020
Statut:
epublish
Résumé
Preterm premature rupture of membranes (pPROM) typically leads to spontaneous preterm birth within several days. In a few rare cases, however, amniotic fluid leakage ceases, amniotic fluid volume is restored, and pregnancy continues until term. Amnion, the collagen-rich layer that forms the load-bearing structure of the fetal membrane, has regenerative capacity and has been used clinically to aid in the healing of various wounds including burns, diabetic ulcers, and corneal injuries. In the healing process of ruptured fetal membranes, amnion epithelial cells seem to play a major role with assistance from innate immunity. In a mouse model of sterile pPROM, macrophages are recruited to the injured site. Well-organized and localized inflammatory responses cause epithelial mesenchymal transition of amnion epithelial cells which accelerates cell migration and healing of the amnion. Research on amnion regeneration is expected to provide insight into potential treatment strategies for pPROM.
Identifiants
pubmed: 32625113
doi: 10.3389/fphys.2020.00623
pmc: PMC7311775
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
623Subventions
Organisme : NICHD NIH HHS
ID : P01 HD087150
Pays : United States
Informations de copyright
Copyright © 2020 Mogami and Word.
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