Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson's Disease.
Parkinson’s disease
high-intensity exercise training
motor unit
neuromuscular
transcriptome
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
08
01
2020
accepted:
22
05
2020
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
7
7
2020
Statut:
epublish
Résumé
Parkinson's disease (PD) is the most common motor neurodegenerative disease, and neuromuscular function deficits associated with PD contribute to disability. Targeting these symptoms, our laboratory has previously evaluated 16-week high-intensity resistance exercise as rehabilitative training (RT) in individuals with PD. We reported significant improvements in muscle mass, neuromuscular function (strength, power, and motor unit activation), indices of neuromuscular junction integrity, total and motor scores on the unified Parkinson's disease rating scale (UPDRS), and total and sub-scores on the 39-item PD Quality of Life Questionnaire (PDQ-39), supporting the use of RT to reverse symptoms. Our objective was to identify transcriptional networks that may contribute to RT-induced neuromuscular remodeling in PD. We generated transcriptome-wide skeletal muscle RNA-sequencing in 5 participants with PD [4M/1F, 67 ± 2 years, Hoehn and Yahr stages 2 (
Identifiants
pubmed: 32625117
doi: 10.3389/fphys.2020.00653
pmc: PMC7311784
doi:
Types de publication
Journal Article
Langues
eng
Pagination
653Subventions
Organisme : NICHD NIH HHS
ID : P2C HD086851
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD071866
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK112331
Pays : United States
Informations de copyright
Copyright © 2020 Lavin, Ge, Sealfon, Nair, Wilk, McAdam, Windham, Kumar, McDonald and Bamman.
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