The Importance of Mechanical Forces for

(lymph-)angiogenesis ECM - extracellular matrix blood endothelial cells fluid shear stress in vitro model culture system lymphatic endothelial cells matrix stiffness mechanotransduction

Journal

Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006

Informations de publication

Date de publication:
2020
Historique:
received: 27 02 2020
accepted: 26 05 2020
entrez: 7 7 2020
pubmed: 7 7 2020
medline: 7 7 2020
Statut: epublish

Résumé

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with their luminal and abluminal extracellular environments. These interactions confer physical forces on the endothelium, such as shear stress, stretch and stiffness, to mediate biological responses. These physical forces are often altered during disease, driving abnormal endothelial cell behavior and pathology. Therefore, it is critical that we understand the mechanisms by which endothelial cells respond to physical forces. Traditionally, endothelial cells in culture are grown in the absence of flow on stiff substrates such as plastic or glass. These cells are not subjected to the physical forces that endothelial cells endure

Identifiants

pubmed: 32625119
doi: 10.3389/fphys.2020.00684
pmc: PMC7314997
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

684

Informations de copyright

Copyright © 2020 Gordon, Schimmel and Frye.

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Auteurs

Emma Gordon (E)

Division of Cell and Developmental Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.

Lilian Schimmel (L)

Division of Cell and Developmental Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.

Maike Frye (M)

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Classifications MeSH