Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity.
liver fat content
non-alcocholic fatty liver disease
pediatric nonalcoholic fatty liver disease
pediatric obesity
serum ferritin
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
11
02
2020
accepted:
30
04
2020
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
29
5
2021
Statut:
epublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) contributes essentially to the burden of obesity and can start in childhood. NAFLD can progress to cirrhosis and hepatocellular carcinoma. The early phase of NAFLD is crucial because during this time the disease is fully reversible. Pediatric NAFLD shows unique features of histology and pathophysiology compared to adults. Changes in serum iron parameters are common in adult NAFLD and have been termed dysmetabolic iron overload syndrome characterized by increased serum ferritin levels and normal transferrin saturation; however, the associations of serum ferritin, inflammation, and liver fat content have been incompletely investigated in children. As magnetic resonance imaging (MRI) is an excellent measure for the degree of liver steatosis, we applied this method herein to clarify the interaction between ferritin and fatty liver in male adolescents. For this study, one hundred fifty male pediatric patients with obesity and who are overweight were included. We studied a subgroup of male patients with (
Identifiants
pubmed: 32625166
doi: 10.3389/fendo.2020.00340
pmc: PMC7314945
doi:
Substances chimiques
Biomarkers
0
Ferritins
9007-73-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
340Informations de copyright
Copyright © 2020 Mörwald, Aigner, Bergsten, Brunner, Forslund, Kullberg, Ahlström, Manell, Roomp, Schütz, Zsoldos, Renner, Furthner, Maruszczak, Zandanell, Weghuber and Mangge.
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