Safety of cassia gum as a feed additive for cats and dogs based on a dossier submitted by Glycomer GmbH.
anthraquinone
cassia gum
cats
dogs
genotoxicity
mutagenicity
safety
Journal
EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
entrez:
7
7
2020
pubmed:
17
1
2019
medline:
17
1
2019
Statut:
epublish
Résumé
The additive cassia gum consists mainly of high-molecular weight polysaccharides composed primarily of a linear chain of 1,4-β-d-mannopyranose units with 1,6-linked α-d-galactopyranose units. In 2014, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) delivered an opinion on the safety and efficacy of cassia gum in cats and dogs. The Panel concluded, based on positive findings observed in a bacterial reverse mutation test with a semi-refined cassia gum (about 70 mg anthraquinones/kg) but not with purified semi-refined cassia gum that meets the specification as a food additive (< 0.5 mg anthraquinones/kg), that only purified semi-refined cassia gum that meets the specifications of cassia gum as a food additive can be considered safe for cats and dogs, at a maximum content of 1.5% cassia gum (15,000 mg/kg feed) in dry matter, corresponding to 1.32% (13,200 mg/kg feed) in a standardised complete feed with 12% water content. The conclusion was confirmed in an opinion delivered by the Panel in 2017. Following this opinion, the European Commission gave the possibility to the applicant to submit complementary information on the safety for cats and dogs. The semi-refined cassia gum under application was mutagenic in a bacterial reverse mutation test in
Identifiants
pubmed: 32626074
doi: 10.2903/j.efsa.2019.5528
pii: EFS25528
pmc: PMC7009261
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e05528Informations de copyright
© 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.