Re-evaluation of benzyl alcohol (E 1519) as food additive.
E 1519
acceptable daily intake
benzyl alcohol
dietary exposure
food additive
risk assessment
safety
Journal
EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
7
7
2020
Statut:
epublish
Résumé
The Panel on Food Additives and Flavourings (FAF) provided a scientific opinion re-evaluating the safety of benzyl alcohol (E 1519) when used as a food additive. The Panel considered that adequate exposure and toxicity data were available. Benzyl alcohol (E 1519) is authorised as a food additive in the EU in accordance with Annex III to Regulation (EC) No 1333/2008. The Panel considered benzyl alcohol of low acute toxicity with no concern with respect to genotoxicity and carcinogenicity and established an acceptable daily intake (ADI) of 4 mg/kg body weight (bw) per day based on a no observable adverse effect level (NOAEL) of 400 mg/kg bw per day from the carcinogenicity study in rats. The mean and high exposure estimates in the refined exposure scenarios were maximally 0.27 and 0.81 mg/kg bw per day in toddlers, respectively. The exposure estimates to benzyl alcohol (E 1519) were below the ADI of 4 mg/kg bw per day in all population groups. The Panel noted that also the exposure in the
Identifiants
pubmed: 32626148
doi: 10.2903/j.efsa.2019.5876
pii: EFS25876
pmc: PMC7008871
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e05876Informations de copyright
© 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Références
Arch Dermatol. 1984 Sep;120(9):1200-1
pubmed: 6236755
Immunol Allergy Clin North Am. 2018 Feb;38(1):27-37
pubmed: 29132672
J Pharmacol Exp Ther. 1945 Aug;84:358-62
pubmed: 21004430
Food Chem. 2014 Jul 1;154:151-7
pubmed: 24518327
Mutat Res. 2012 Feb 18;742(1-2):11-25
pubmed: 22138618
AMA Arch Ind Hyg Occup Med. 1951 Aug;4(2):119-22
pubmed: 14856438
Food Chem Toxicol. 2010 May;48(5):1239-42
pubmed: 20170703
Food Chem Toxicol. 1984 Aug;22(8):623-36
pubmed: 6381265
Clin Rev Allergy Immunol. 1995 Fall;13(3):253-63
pubmed: 8535931
Teratog Carcinog Mutagen. 1987;7(1):29-48
pubmed: 2884741
Food Chem Toxicol. 2012 Sep;50 Suppl 2:S269-313
pubmed: 22407231
Food Chem Toxicol. 2001 Dec;39(12):1199-204
pubmed: 11696393
Natl Toxicol Program Tech Rep Ser. 1989 Jun;343:1-158
pubmed: 12724782
Toxicol Appl Pharmacol. 2003 Jun 1;189(2):120-33
pubmed: 12781630
Food Chem Toxicol. 1988 Jun;26(6):487-500
pubmed: 3169648
Eur J Clin Pharmacol. 1991;41(4):363-8
pubmed: 1804654
Food Chem. 2016 Dec 15;213:378-387
pubmed: 27451194
J Agric Food Chem. 2000 Sep;48(9):4290-3
pubmed: 10995351
Food Cosmet Toxicol. 1967 Apr;5(2):141-57
pubmed: 6068552
Food Chem. 2011 Aug 1;127(3):1153-62
pubmed: 25214108
Phytochemistry. 2012 Feb;74:196-205
pubmed: 22071134
Int J Toxicol. 2001;20 Suppl 3:23-50
pubmed: 11766131
Molecules. 2018 Jul 19;23(7):
pubmed: 30029465
J Agric Food Chem. 2011 Aug 10;59(15):8358-65
pubmed: 21702480
Allergy. 2004 Sep;59(9):1023-4
pubmed: 15291924
Methods Find Exp Clin Pharmacol. 1993 Apr;15(3):141-52
pubmed: 8332030
Environ Mol Mutagen. 2004;44(4):329-45
pubmed: 15476194
Food Chem Toxicol. 2015 Oct;84 Suppl:S1-S14
pubmed: 26364874
J Agric Food Chem. 2011 Mar 23;59(6):2524-33
pubmed: 21341698
Sangyo Igaku. 1994 Sep;36(5):314-23
pubmed: 7967156
J Pharm Biomed Anal. 2006 Jun 16;41(4):1380-5
pubmed: 16564153
Food Chem. 2016 Jan 1;190:1116-1122
pubmed: 26213084
Drug Intell Clin Pharm. 1986 Sep;20(9):689-91
pubmed: 3757780
Food Technol Biotechnol. 2017 Sep;55(3):333-359
pubmed: 29089848
Food Chem Toxicol. 2005 Aug;43(8):1207-40
pubmed: 15950815
Chem Biol Interact. 1986 Jun;58(3):253-75
pubmed: 3527455
Mutat Res. 1996 Jun 12;368(2):59-101
pubmed: 8684406
EFSA J. 2019 Oct 30;17(10):e05876
pubmed: 32626148
Food Chem Toxicol. 2012 Sep;50 Suppl 2:S140-60
pubmed: 22036973
N Engl J Med. 1982 Jan 14;306(2):108
pubmed: 7053477