Safety and efficacy of a molybdenum compound (E7) sodium molybdate dihydrate as feed additive for sheep based on a dossier submitted by Trouw Nutrition International B.V.
compounds of trace elements
efficacy
molybdenum
nutritional additive
safety
sheep
sodium molybdate dihydrate
Journal
EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
entrez:
7
7
2020
pubmed:
27
2
2019
medline:
27
2
2019
Statut:
epublish
Résumé
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on safety and efficacy of sodium molybdate dihydrate for sheep, based on a dossier submitted for the re-evaluation of the additive. The additive is currently authorised in the EU for all animal species as 'Nutritional additive' - 'Compounds of trace elements'. Taking the optimal Cu:Mo ratio of 3-10, and the highest total copper level authorised in complete feeds for sheep (15 mg/kg), the FEEDAP Panel concluded that 2.5 mg total Mo/kg complete feed is safe for sheep. Considering (i) a safe intake of 0.6 mg Mo/day, (ii) the estimate average intake figure from food in Europe (generally less than 100 μg/day), (iii) the contribution of foods of animal origin to the total molybdenum intake (estimated to be up to 22 %), and (iv) that molybdenum would not accumulate in edible tissues/products of sheep fed molybdenum supplemented diets up to the upper safe level, the FEEDAP Panel concluded that the use of sodium molybdate as a additive in sheep at 2.5 mg total Mo/kg complete feed is safe for consumers. The additive under assessment feed poses no risk by inhalation to users; it is a skin and eye irritant, but it is not considered as a skin sensitiser. Sodium molybdate used up to 2.5 mg Mo/kg complete sheep feed poses no concerns for the safety for the environment. The FEEDAP Panel recognises that molybdenum does not need to be added to diets to cover the nutritional needs of molybdenum of sheep. Molybdenum supplementation in sheep feed is considered effective in order to guarantee an adequate balance with copper, when the Cu:Mo ratio in the diet is in the range 3-10.
Identifiants
pubmed: 32626229
doi: 10.2903/j.efsa.2019.5606
pii: EFS25606
pmc: PMC7009221
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e05606Informations de copyright
© 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Références
Annu Rev Nutr. 1988;8:401-27
pubmed: 3060171
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10723-8
pubmed: 11005854
Vet Rec. 1986 Dec 13;119(24):596-8
pubmed: 3811176
J Appl Toxicol. 1999 May-Jun;19(3):185-92
pubmed: 10362269
Regul Toxicol Pharmacol. 2014 Dec;70(3):579-88
pubmed: 24041747
Mutat Res. 1975 Jun;31(3):185-9
pubmed: 805366
Mutat Res. 1983 Apr;117(1-2):149-52
pubmed: 6339905
Arch Environ Health. 1979 Sep-Oct;34(5):302-8
pubmed: 496425
Biol Trace Elem Res. 2019 Jul;190(1):234-241
pubmed: 30232748
J Toxicol Clin Toxicol. 1999;37(2):231-7
pubmed: 10382558
EFSA J. 2019 Feb 27;17(2):e05606
pubmed: 32626229
J Nutr. 2003 May;133(5 Suppl 1):1506S-9S
pubmed: 12730454
Nature. 1960 Jan 2;185:20-2
pubmed: 14422643
Biometals. 2002 Mar;15(1):65-72
pubmed: 11860024
Br J Nutr. 1989 Mar;61(2):355-71
pubmed: 2706232
Nutr Res Rev. 2011 Dec;24(2):176-82
pubmed: 22296933
Vet Rec. 1982 Sep 25;111(13):299-301
pubmed: 7147642
Br J Nutr. 1987 Jul;58(1):127-38
pubmed: 3620434
Semin Cell Dev Biol. 2011 Aug;22(6):637-44
pubmed: 21893209
J Anim Sci. 1978 Apr;46(4):1078-85
pubmed: 353014
Environ Mol Mutagen. 1998;32(3):251-9
pubmed: 9814440
Regul Toxicol Pharmacol. 2017 Jun;86:279-291
pubmed: 28342846
J Anim Sci. 1984 Jul;59(1):210-6
pubmed: 6746453
Proc Nutr Soc. 1969 Sep;28(2):189-98
pubmed: 4901031
Agents Actions. 1976 Nov;6(6):758-69
pubmed: 1008022
Natl Toxicol Program Tech Rep Ser. 1997 Apr;462:1-269
pubmed: 12587014