Scientific Opinion on Flavouring Group Evaluation 70, Revision 1 (FGE.70Rev1): consideration of aliphatic, linear, α,β-unsaturated, di- and trienals and related alcohols, acids and esters evaluated by JECFA (61st-68th-69th meeting).
FGE.70
JECFA
flavourings
α,β‐unsaturated carbonyls and precursors
Journal
EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
7
7
2020
Statut:
epublish
Résumé
The EFSA Panel on Food Additives and Flavourings was requested to evaluate 29 flavouring substances attributed to the Flavouring Group Evaluation 70 (FGE.70), using the Procedure in Commission Regulation (EC) No 1565/2000. Seven substances have already been considered in FGE.70 [FL-no: 08.085, 09.194, 09.260, 09.300, 09.371, 09.639 and 09.840]. The remaining 22 substances [FL-no: 02.049, 05.058, 05.111, 05.120, 05.172, 09.947, 02.139, 02.153, 02.162, 02.188, 05.057, 05.064, 05.071, 05.084, 05.101, 05.108, 05.125, 05.127, 05.140, 05.141, 05.173 and 09.573] have been cleared with respect to genotoxicity in FGE.200Rev1 and FGE.203Rev2 and are considered in this revision. The substances were evaluated through a stepwise approach that integrates information on the structure-activity relationships, intake from current uses, toxicological threshold of concern (TTC), and available data on metabolism and toxicity. The Panel concluded that none of the 29 substances gives rise to safety concerns at their levels of dietary intake, estimated on the basis of the 'Maximised Survey-derived Daily Intake' (MSDI) approach. Besides the safety assessment of the flavouring substances, the specifications for the materials of commerce have also been considered and found adequate, except for [FL-no: 09.371 and 09.840]. For these two substances, data on the composition of the stereoisomeric mixture should be requested. Data on the identity and contents of secondary components should be requested for [FL no: 09.260]. Normal and maximum use levels should be provided for seven flavouring substances [FL-no: 08.085, 09.194, 09.260, 09.300, 09.371, 09.639 and 09.840]. For six flavouring substances [FL-no: 05.057, 05.058, 05.111, 05.120, 05.172 and 09.947] further information is required based on the comparison of the 'modified Theoretical Added Maximum Daily Intakes' (mTAMDIs) with the TTCs. This includes more reliable data on use and use levels and then, if required, additional toxicological data.
Identifiants
pubmed: 32626369
doi: 10.2903/j.efsa.2019.5749
pii: EFS25749
pmc: PMC7009153
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e05749Informations de copyright
© 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Références
World Health Organ Tech Rep Ser. 1999;884:i-viii, 1-96
pubmed: 10079756
EFSA J. 2019 Jun 06;17(6):e05708
pubmed: 32626331
Toxicol Lett. 1986 May;31(2):101-6
pubmed: 3715920
EFSA J. 2019 Mar 01;17(3):e05625
pubmed: 32626251
EFSA J. 2019 Jul 17;17(7):e05749
pubmed: 32626369
Food Cosmet Toxicol. 1978 Jun;16(3):255-76
pubmed: 357272
EFSA J. 2018 Oct 19;16(10):e05422
pubmed: 32625707
World Health Organ Tech Rep Ser. 1997;868:i-viii, 1-69
pubmed: 9385867
EFSA J. 2018 Jul 20;16(7):e05322
pubmed: 32625963