Scientific Opinion on Flavouring Group Evaluation 5, Revision 3 (FGE.05Rev3): Branched- and straight-chain unsaturated aldehydes, dienals, unsaturated and saturated carboxylic acids and related esters with saturated and unsaturated aliphatic alcohols and a phenylacetic acid related ester from chemical groups 1, 2, 3, 5 and 15.
FGE.05
flavourings
α,β‐unsaturated carbonyls and precursors
Journal
EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
7
7
2020
Statut:
epublish
Résumé
The EFSA Panel on Food Additives and Flavourings (FAF) was requested to evaluate 54 flavouring substances attributed to the Flavouring Group Evaluation 05 (FGE.05), using the Procedure as referred to in the Commission Regulation (EC) No 1565/2000. This Revision 3 includes 17 additional substances which have been cleared with respect to genotoxicity in FGE.200Rev1 ([FL-no: 02.192, 02.231, 05.072, 05.144, 05.184, 05.189, 05.190, 05.191, 05.195, 09.247, 09.400, 09.866, 09.948]) and in FGE.203Rev2 ([FL-no: 05.081, 05.186, 05.194, 05.196]). The substances were evaluated through a stepwise approach that integrates information on the structure-activity relationships, intake from current uses, toxicological threshold of concern (TTC), and available data on metabolism and toxicity. The Panel concluded that none of the 54 substances gives rise to safety concern at their levels of dietary intake, estimated on the basis of the 'Maximised Survey-derived Daily Intake' (MSDI) approach. Besides the safety assessment of the flavouring substances, the specifications for the materials of commerce have also been considered and found adequate, except for 10 substances ([FL-no: 08.072, 08.083, 08.101, 08.119, 08.120, 09.181, 09.329, 09.335, 09.379 and 09.637]) for which quantitative figures on the composition of stereoisomeric mixtures are missing and for [FL-no: 09.578] complete specifications should be provided. Normal and maximum use levels were not available for [FL-no: 08.072, 08.083, 08.101, 08.119, 08.120, 09.287, 09.326 and 09.578]. Except for flavouring substances [FL-no: 05.072, 05.081, 05.186, 05.194, 05.196, 09.934 and 09.942], more reliable intake data should be requested for all the 46 flavouring substances, for which use levels were submitted, as their modified Theoretical Added Maximum Daily Intake (mTAMDI) exposure estimates are above the threshold of concern for structural classes I and II. This would include more reliable intake data and then, if required, additional toxicological data.
Identifiants
pubmed: 32626377
doi: 10.2903/j.efsa.2019.5761
pii: EFS25761
pmc: PMC7009289
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e05761Informations de copyright
© 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Références
World Health Organ Tech Rep Ser. 1999;884:i-viii, 1-96
pubmed: 10079756
EFSA J. 2019 Jun 06;17(6):e05708
pubmed: 32626331
FAO Food Nutr Pap. 1998;52 Add 6:1-219
pubmed: 10374078
Clin Chim Acta. 1971 Nov;35(1):121-31
pubmed: 5126986
Food Cosmet Toxicol. 1978 Jun;16(3):255-76
pubmed: 357272
Food Chem Toxicol. 1983 Oct;21(5):543-9
pubmed: 6686181
EFSA J. 2019 Jul 17;17(7):e05749
pubmed: 32626369
EFSA J. 2018 Oct 19;16(10):e05422
pubmed: 32625707
World Health Organ Tech Rep Ser. 1997;868:i-viii, 1-69
pubmed: 9385867
EFSA J. 2018 Jul 20;16(7):e05322
pubmed: 32625963
EFSA J. 2019 Jul 31;17(7):e05761
pubmed: 32626377
Food Cosmet Toxicol. 1969 Sep;7(5):451-9
pubmed: 5351709