Advancing human health risk assessment.
alternative methods
epidemiology
exposure
food safety
mechanistic studies
risk assessment
Journal
EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
7
7
2020
Statut:
epublish
Résumé
The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal-free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re-engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break-out session 'Advancing risk assessment science - Human health' at EFSA's third Scientific Conference 'Science, Food and Society' (Parma, Italy, 18-21 September 2018).
Identifiants
pubmed: 32626449
doi: 10.2903/j.efsa.2019.e170712
pii: EFS2E170712
pmc: PMC7015480
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e170712Subventions
Organisme : World Health Organization
ID : 001
Pays : International
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom
Informations de copyright
© 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Références
Arch Toxicol. 2014 Dec;88(12):2289-314
pubmed: 25270621
ALTEX. 2015;32(4):327-78
pubmed: 26536291
Nat Rev Rheumatol. 2015 Aug;11(8):450-61
pubmed: 25986717
Science. 2010 Oct 22;330(6003):460-1
pubmed: 20966241
Arch Toxicol. 2016 May;90(5):1021-4
pubmed: 27017488
Front Genet. 2017 Dec 19;8:222
pubmed: 29312443
Toxicol Appl Pharmacol. 2018 Sep 1;354:3-6
pubmed: 29447839
Bone. 2012 Jun;50(6):1372-8
pubmed: 22465267
Food Chem Toxicol. 2019 Mar;125:341-353
pubmed: 30553876
Arch Toxicol. 2013 Apr;87(4):563-7
pubmed: 23503654
ALTEX. 2008;25(2):91-102
pubmed: 18551232
Arch Toxicol. 2016 Oct;90(10):2531-62
pubmed: 27439414
Environ Health. 2014 Dec 10;13:106
pubmed: 25495114
EFSA J. 2017 Jan 24;15(1):e04658
pubmed: 32625254
Food Chem Toxicol. 2012 Nov;50(11):4221-31
pubmed: 22999595
Int J Epidemiol. 2012 Feb;41(1):24-32
pubmed: 22296988
Neurotoxicology. 2012 Aug;33(4):911-24
pubmed: 22008243
Environ Health Perspect. 2013 Jul;121(7):A206-7
pubmed: 23817036
EFSA J. 2019 Jul 08;17(Suppl 1):e170712
pubmed: 32626449
ALTEX. 2017;34(1):49-74
pubmed: 27452664
EFSA J. 2019 Jul 08;17(Suppl 1):e170711
pubmed: 32626448
Appetite. 2017 Jun 1;113:320-326
pubmed: 28315418
EFSA J. 2023 Apr 19;21(4):e06857
pubmed: 37089179
ALTEX. 2017;34(2):311-315
pubmed: 28407175
Reprod Toxicol. 2013 Sep;40:35-40
pubmed: 23747832
ALTEX. 2018;35(3):275-305
pubmed: 30008008
Regul Toxicol Pharmacol. 2014 Oct;70(1):297-303
pubmed: 25046166
EFSA J. 2019 Jul 08;17(Suppl 1):e170710
pubmed: 32626447
Int J Hyg Environ Health. 2017 Mar;220(2 Pt A):94-97
pubmed: 28284775
Eur J Cancer. 2018 Nov;103:317-326
pubmed: 29903684
J Bone Miner Res. 2011 Mar;26(3):486-95
pubmed: 20734452
ALTEX. 2014;31(2):129-56
pubmed: 24687333
ALTEX. 2015;32(3):171-81
pubmed: 26168280
ALTEX. 2008;25(2):103-14
pubmed: 18551234
EFSA J. 2017 Jun 22;15(6):e04862
pubmed: 32728397
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50
pubmed: 16103423
ALTEX. 2015;32(4):261-74
pubmed: 26536288
Toxicol Lett. 2010 Sep 15;198(1):44-8
pubmed: 20447450
ALTEX. 2014;31(4):479-93
pubmed: 25027442
Toxicol Appl Pharmacol. 2014 Sep 15;279(3):364-372
pubmed: 24998972
Arch Toxicol. 2017 Nov;91(11):3477-3505
pubmed: 29051992
ALTEX. 2019;36(1):3-17
pubmed: 30633302
Chemosphere. 2010 Nov;81(10):1171-83
pubmed: 21030064
ALTEX. 2016;33(3):272-321
pubmed: 27180100
Arch Toxicol. 2017 Apr;91(4):1977-2006
pubmed: 27730258
Front Biosci (Landmark Ed). 2012 Jun 01;17(7):2442-60
pubmed: 22652791
ALTEX. 2014;31(3):341-56
pubmed: 25061899
Arch Toxicol. 2017 Jan;91(1):1-33
pubmed: 27492622
EFSA J. 2019 Jul 08;17(Suppl 1):e170704
pubmed: 32626441
Reprod Toxicol. 2015 Dec;58:33-44
pubmed: 26232693
Annu Rev Nutr. 2018 Aug 21;38:459-479
pubmed: 29801421
Toxicol Appl Pharmacol. 2015 Dec 15;289(3):442-56
pubmed: 26522835
ALTEX. 2012;29(1):3-91
pubmed: 22307314
Environ Res. 1978 Jul;16(1-3):248-69
pubmed: 679914
ALTEX. 2018 Feb 23;35(3):306-352
pubmed: 29485663
Arch Toxicol. 2015 Feb;89(2):269-87
pubmed: 25618548
ALTEX. 2013;30(2):209-25
pubmed: 23665807
Pharmacol Ther. 2017 Nov;179:84-95
pubmed: 28529068
Int J Hyg Environ Health. 2017 Mar;220(2 Pt A):142-151
pubmed: 27576363
Eur J Epidemiol. 2018 Apr;33(4):355-363
pubmed: 29680996