Joint venture on the further development of chemical exposure assessment by use of probabilistic modelling.

dietary exposure probabilistic modelling risk assessment

Journal

EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076

Informations de publication

Date de publication:
Sep 2019
Historique:
entrez: 7 7 2020
pubmed: 7 7 2020
medline: 7 7 2020
Statut: epublish

Résumé

Exposure assessment is a fundamental component of the risk assessment process and has a significant contribution to the overall uncertainty of the risk estimates. The aim of the present project, implemented within the framework of the EU-FORA Fellowship, was to develop a structured approach for probabilistic modelling of the dietary exposure to chemical contaminants, which shall be used as a refined alternative to the more conservative deterministic approach or as part of a Tier 2 assessment. The fellow received training and worked in close cooperation with the project team on three case studies of contaminants in food (cadmium, acrylamide and deoxynivalenol). The modelling of the dietary intake was based on relevant EFSA Guidance and employed the Monte Carlo simulation methodology with the use of a standard software tool (Monte Carlo Risk Assessment (MCRA) platform) and/or a tailor-made risk model in the programming language

Identifiants

pubmed: 32626463
doi: 10.2903/j.efsa.2019.e170905
pii: EFS2E170905
pmc: PMC7015474
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e170905

Informations de copyright

© 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.

Références

Rev Environ Contam Toxicol. 2017;241:73-137
pubmed: 27300014
Environ Int. 2016 Mar;88:299-309
pubmed: 26851498
Crit Rev Toxicol. 2010 Jul;40(6):485-512
pubmed: 20170357
Toxicol Appl Pharmacol. 2005 Nov 1;208(3):199-209
pubmed: 16239164
IARC Sci Publ. 1992;(118):301-10
pubmed: 1303956
Nature. 2002 Oct 3;419(6906):448-9
pubmed: 12368844
Food Chem Toxicol. 2002 Feb-Mar;40(2-3):327-85
pubmed: 11893401
Arch Toxicol. 2007 May;81(5):327-34
pubmed: 17031680
J Toxicol Environ Health. 1996 May;48(1):1-34
pubmed: 8637056
Toxins (Basel). 2014 Jan 28;6(2):430-52
pubmed: 24476707
Appl Environ Microbiol. 1985 Aug;50(2):482-6
pubmed: 4051489
Curr Diabetes Rev. 2016;12(3):252-8
pubmed: 26264451
Toxicol Lett. 2008 Jun 30;179(2):108-12
pubmed: 18515022

Auteurs

Classifications MeSH