Scientific Opinion on Flavouring Group Evaluation 71 Revision 1 (FGE.71Rev1): consideration of aliphatic, linear, α,β-unsaturated alcohols, aldehydes, carboxylic acids, and related esters evaluated by JECFA (63rd and 69th meeting) structurally related to flavouring substances evaluated in FGE.05Rev3.
FGE.71
JECFA
flavourings
αβ‐unsaturated carbonyls and precursors
Journal
EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
entrez:
7
7
2020
pubmed:
7
7
2020
medline:
7
7
2020
Statut:
epublish
Résumé
The EFSA Panel on Food Additives and Flavourings was requested to evaluate 39 flavouring substances assigned to the Flavouring Group Evaluation 71 (FGE.71), using the Procedure in Commission Regulation (EC) No 1565/2000. Nine substances have already been considered in FGE.71 [FL-no: 08.054, 08.073, 08.123, 09.037, 09.156, 09.157, 05.158, 09.235, 09.239]. The remaining 30 substances [FL-no: 02.020, 02.050, 02.090, 02.112, 02.137, 02.156, 02.210, 05.037, 05.060, 05.070, 05.073, 05.076, 05.078, 05.102, 05.109, 05.150, 05.171, 05.179, 09.276, 09.277, 09.303, 09.385, 09.394, 09.395, 09.396, 09.397, 09.398, 09.399, 09.678 and 09.841] have been cleared with respect to genotoxicity in FGE.200Rev1 and they are considered in this revision. The substances were evaluated through a stepwise approach that integrates information on the structure-activity relationships, intake from current uses, toxicological threshold of concern (TTC), and available data on metabolism and toxicity. The Panel concluded that none of the 39 substances gives rise to safety concerns at their levels of dietary intake, estimated on the basis of the 'Maximised Survey-derived Daily Intake' (MSDI) approach. Besides the safety assessment of the flavouring substances, the specifications for the materials of commerce have also been considered and found adequate, except for [FL-no: 08.073 and 09.235]. For these two substances, data on the composition of the stereoisomeric mixture should be requested. Normal and maximum use levels should be provided for nine flavouring substances [FL-no: 08.054, 08.073, 08.123, 09.037, 09.156, 09.157, 05.158, 09.235, 09.239]. For two flavouring substances [FL-no: 02.020 and 05.076], the 'modified Theoretical Added Maximum Daily Intake' (mTAMDI) estimates are above the TTC for their structural class I. Therefore, additional information on uses and use levels should be provided for these eleven substances in order to finalise their evaluation.
Identifiants
pubmed: 32626481
doi: 10.2903/j.efsa.2020.5924
pii: EFS25924
pmc: PMC7008796
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e05924Informations de copyright
© 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Références
World Health Organ Tech Rep Ser. 1999;884:i-viii, 1-96
pubmed: 10079756
EFSA J. 2020 Jan 09;18(1):e05924
pubmed: 32626481
Arch Toxicol. 2013 Sep;87(9):1725-37
pubmed: 23864024
Food Cosmet Toxicol. 1971 Dec;9(6):775-86
pubmed: 5144118
EFSA J. 2019 Jul 17;17(7):e05749
pubmed: 32626369
EFSA J. 2019 Jul 31;17(7):e05761
pubmed: 32626377
Chem Res Toxicol. 2012 Dec 17;25(12):2630-41
pubmed: 22978292
EFSA J. 2019 Jun 06;17(6):e05708
pubmed: 32626331
Toxicol Pathol. 2008 Feb;36(2):232-46
pubmed: 18362197
Cardiovasc Toxicol. 2003;3(4):341-51
pubmed: 14734831
Food Cosmet Toxicol. 1978 Jun;16(3):255-76
pubmed: 357272
EFSA J. 2018 Oct 19;16(10):e05422
pubmed: 32625707
World Health Organ Tech Rep Ser. 1997;868:i-viii, 1-69
pubmed: 9385867