Highly sensitive retrospective determination of organophosphorous nerve agent biomarkers in human urine implemented in vivo in rabbit.
Alkyl methylphosphonic acids (AMPAs)
Ba/Ag/H
LC–MS/MS
Nerve agents
Urine
ZrO2
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
21
03
2020
accepted:
24
06
2020
pubmed:
7
7
2020
medline:
17
6
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
Highly toxic organophosphorous nerve agents (OPAs) have been used in several armed conflicts and terror attacks in the last few decades. A new method for retrospective determination of alkyl methylphosphonic acid (AMPA) metabolites in urine after exposure to VX, GB and GF nerve agents was developed. This method enables a rapid, sensitive and selective determination of trace levels of the nerve agent biomarkers ethyl methylphosphonic acid (EMPA), isopropyl methylphosphonic acid (IMPA) and cyclohexyl methylphosphonic acid (CMPA) in urine. The new technique involves a unique combination of two solid phase extraction (SPE) cartridges: a Ba/Ag/H cartridge for urine interference removal, and a ZrO
Identifiants
pubmed: 32627075
doi: 10.1007/s00204-020-02827-x
pii: 10.1007/s00204-020-02827-x
doi:
Substances chimiques
Biomarkers
0
Chemical Warfare Agents
0
Nerve Agents
0
Organophosphonates
0
Organophosphorus Compounds
0
ethyl methylphosphonic acid
1832-53-7
isopropyl methylphosphonic acid
1832-54-8
cyclohexyl methylphosphonic acid
1932-60-1
methylphosphonic acid
329W4YM10Z
Sarin
B4XG72QGFM
cyclohexyl methylphosphonofluoridate
VM36F9N236
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM