Combination of curcumin with autologous transplantation of adult neural stem/progenitor cells leads to more efficient repair of damaged cerebral tissue of rat.
PuraMatrix
autologous transplantation
brain injury
curcumin
neural stem cells
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
15
04
2020
accepted:
16
06
2020
pubmed:
7
7
2020
medline:
21
10
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
What is the central question of this study? Can the neuroprotective agent curcumin affect restorative action of neural stem/progenitor cells in the injured rat brain? What is the main finding and its importance? In the presence of curcumin, transplantation of neural stem/progenitor cells in the context of PuraMatrix reduced lesion size and reactive inflammatory responses, and boosted survival rate of grafted neurons. In addition it improved the neurological status of injured animals. This could be beneficial in designing new therapeutic approaches for brain injury based on this combination therapy. Traumatic brain injury (TBI) is catastrophic neurological damage associated with substantial morbidity and mortality. To date, there is no specific treatment for restoring lost brain tissue. In light of the complex pathology of brain injury, the present study evaluated the effects of combination therapy using autologous neural stem/progenitor cells (NS/PCs), PuraMatrix (PM) and curcumin in an animal model of brain injury. After stereotactic biopsy of subventricular zone tissue and culture of NS/PCs, 36 male Wistar rats (150-200 g) were randomly divided into six groups receiving dimethyl sulfoxide (DMSO), curcumin (100 mg kg
Substances chimiques
Dcx protein, rat
0
Doublecortin Protein
0
Neuroprotective Agents
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1610-1622Subventions
Organisme : Tehran University of Medical Sciences
Organisme : Shefa Neuroscience Research Center
ID : 90-3-87-14565
Informations de copyright
© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.
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