C-H/C-C Functionalization Approach to N-Fused Heterocycles from Saturated Azacycles.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
29 07 2020
29 07 2020
Historique:
pubmed:
7
7
2020
medline:
16
4
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
Herein we report the synthesis of substituted indolizidines and related N-fused bicycles from simple saturated cyclic amines through sequential C-H and C-C bond functionalizations. Inspired by the Norrish-Yang Type II reaction, C-H functionalization of azacycles is achieved by forming α-hydroxy-β-lactams from precursor α-ketoamide derivatives under mild, visible light conditions. Selective cleavage of the distal C(sp
Identifiants
pubmed: 32627545
doi: 10.1021/jacs.0c04278
pmc: PMC7773224
mid: NIHMS1656304
doi:
Substances chimiques
Aza Compounds
0
Heterocyclic Compounds
0
Indolizidines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
13041-13050Subventions
Organisme : NIH HHS
ID : S10 OD024998
Pays : United States
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