SLC2A3 rs12842 polymorphism and risk for Alzheimer's disease.

Aged Aged, 80 and over Alzheimer Disease / epidemiology Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease Genotype Glucose Transporter Type 3 / genetics Humans Male Odds Ratio Polymorphism, Single Nucleotide
AD SLC2A3 genetics polymorphism rs12842 SNPs

Journal

Neurological research
ISSN: 1743-1328
Titre abrégé: Neurol Res
Pays: England
ID NLM: 7905298

Informations de publication

Date de publication:
Oct 2020
Historique:
pubmed: 7 7 2020
medline: 25 6 2021
entrez: 7 7 2020
Statut: ppublish

Résumé

Many studies support the hypothesis that brain glucose dysregulation contributes to neurodegeneration and disease progression. The SLC2A3 gene encodes the Neuronal Glucose Transporter 3 (GLUT3), a critical molecule for glucose transport into the neuron. The GLUT3 rs12842 polymorphism has been associated with an increased risk for attention-deficit/hyperactivity disorder (ADHD). Epidemiological and genetic studies have reported a link between antecedent ADHD and Alzheimer's disease (AD), as both share a dysregulation of brain glucose. This study aimed to explore the possible correlation of the SLC2A3 rs12842 polymorphism with susceptibility towards AD. We genotyped 327 patients with AD and 327 controls for the GLUT3 rs12842. Our results suggest a significant, inverse association between SLC2A3 rs12842 and the risk of AD.

Sections du résumé

BACKGROUND BACKGROUND
Many studies support the hypothesis that brain glucose dysregulation contributes to neurodegeneration and disease progression. The SLC2A3 gene encodes the Neuronal Glucose Transporter 3 (GLUT3), a critical molecule for glucose transport into the neuron. The GLUT3 rs12842 polymorphism has been associated with an increased risk for attention-deficit/hyperactivity disorder (ADHD). Epidemiological and genetic studies have reported a link between antecedent ADHD and Alzheimer's disease (AD), as both share a dysregulation of brain glucose.
AIM OBJECTIVE
This study aimed to explore the possible correlation of the SLC2A3 rs12842 polymorphism with susceptibility towards AD.
METHODS METHODS
We genotyped 327 patients with AD and 327 controls for the GLUT3 rs12842.
CONCLUSIONS CONCLUSIONS
Our results suggest a significant, inverse association between SLC2A3 rs12842 and the risk of AD.

Identifiants

DOI: 10.1080/01616412.2020.1786973 PMID: 32627711
pubmed: 32627711
doi: 10.1080/01616412.2020.1786973
doi:

Substances chimiques

Glucose Transporter Type 3 0
SLC2A3 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

853-861

Auteurs

Stylianos Arseniou (S)

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa , Larissa, Greece.

Vasileios Siokas (V)

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa , Larissa, Greece.

Athina-Maria Aloizou (AM)

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa , Larissa, Greece.

Polyxeni Stamati (P)

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa , Larissa, Greece.

Alexios-Fotios A Mentis (AA)

Department of Microbiology, University of Thessaly, University Hospital of Larissa , Larissa, Greece.
Public Health Laboratories, Hellenic Pasteur Institute , Athens, Greece.

Zisis Tsouris (Z)

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa , Larissa, Greece.

Metaxia Dastamani (M)

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa , Larissa, Greece.

Eleni Peristeri (E)

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa , Larissa, Greece.

Varvara Valotassiou (V)

Department of Nuclear Medicine, University Hospital of Larissa , Mezourlo Larissa, Greece.

Dimitrios P Bogdanos (DP)

Department of Rheumatology and Clinical Immunology, University General Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly , Larissa, Greece.

Georgios M Hadjigeorgiou (GM)

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa , Larissa, Greece.
Department of Neurology, Medical School, University of Cyprus , Nicosia, Cyprus.

Efthimios Dardiotis (E)

Department of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa , Larissa, Greece.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › SLC2A3 rs12842 polymorphism and risk for...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › SLC2A3 rs12842 polymorphism and risk for...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › SLC2A3 rs12842 polymorphism and risk for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › SLC2A3 rs12842 polymorphism and risk for...
questionsmedicales.fr › Phénomènes génétiques › Fréquence d'allèle › SLC2A3 rs12842 polymorphism and risk for...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › SLC2A3 rs12842 polymorphism and risk for...
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questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Odds ratio › SLC2A3 rs12842 polymorphism and risk for...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › SLC2A3 rs12842 polymorphism and risk for...