Increased monocyte-platelet aggregates and monocyte-endothelial adhesion in healthy individuals with vitamin D deficiency.
Atherosclerosis
/ metabolism
Blood Platelets
/ metabolism
Cell Adhesion
/ physiology
Cells, Cultured
Dietary Supplements
Down-Regulation
/ physiology
Endothelial Cells
/ metabolism
Female
Healthy Volunteers
Human Umbilical Vein Endothelial Cells
Humans
Inflammation
/ metabolism
Male
Monocytes
/ metabolism
Platelet Activation
/ physiology
Receptors, Calcitriol
/ metabolism
Vitamin D
/ metabolism
Vitamin D Deficiency
/ metabolism
atherosclerosis
microfluidics
monocytes
vitamin D
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
07
04
2020
revised:
26
05
2020
accepted:
15
06
2020
pubmed:
7
7
2020
medline:
26
2
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
Vitamin D deficiency is a major public health problem worldwide, linked to several chronic diseases including cardiovascular diseases. While immunomodulatory effects of vitamin D on monocytes have been reported in cardiovascular and metabolic diseases, there is limited understanding on monocyte phenotype in healthy individuals with suboptimal vitamin D levels and without any clinical diseases. In this work, we performed label-free, microfluidic isolation of monocytes, and characterized their functional phenotype using flow cytometry and in vitro vascular models in healthy subjects with (n = 7) and without vitamin D deficiency (n = 16). Vitamin D deficient (VitD-Def) subjects (25(OH)D
Identifiants
pubmed: 32627899
doi: 10.1096/fj.202000822R
doi:
Substances chimiques
Receptors, Calcitriol
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11133-11142Informations de copyright
© 2020 Federation of American Societies for Experimental Biology.
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