Lipocalin 2 deficiency-induced gut microbiota dysbiosis evokes metabolic syndrome in aged mice.
Adipose Tissue
Adiposity
/ genetics
Aging
/ metabolism
Animals
Blood Glucose
/ analysis
Diet, High-Fat
Disease Models, Animal
Dysbiosis
/ blood
Dyslipidemias
/ blood
Female
Gastrointestinal Microbiome
/ genetics
Homeostasis
/ genetics
Lipocalin-2
/ deficiency
Male
Metabolic Syndrome
/ blood
Mice
Mice, Inbred C57BL
Mice, Knockout
Obesity
/ metabolism
dyslipidemias
insulin resistance
microbial-host interactions
obesity
Journal
Physiological genomics
ISSN: 1531-2267
Titre abrégé: Physiol Genomics
Pays: United States
ID NLM: 9815683
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
pubmed:
7
7
2020
medline:
27
5
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
Lipocalin 2 (Lcn2) is a multifunctional innate immune protein that limits microbial overgrowth. Our previous study demonstrated that the gut microbiota directly induces intestinal Lcn2 production, and Lcn2-deficient (
Identifiants
pubmed: 32628083
doi: 10.1152/physiolgenomics.00118.2019
pmc: PMC7473890
doi:
Substances chimiques
Blood Glucose
0
Lipocalin-2
0
Lcn2 protein, mouse
126469-30-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
314-321Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK097865
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL143082
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK097865
Pays : United States
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