The apparition macrophage and Döderlein bacillus is negatively correlated in class I Papanicolaou smear: A morphological examination.
Adult
Aged
Aged, 80 and over
Bacillus
/ pathogenicity
Early Detection of Cancer
/ methods
Female
Humans
Lactobacillus acidophilus
/ pathogenicity
Macrophages
/ pathology
Middle Aged
Papanicolaou Test
/ methods
Uterine Cervical Neoplasms
/ pathology
Vagina
/ microbiology
Vaginitis
/ diagnosis
Young Adult
Döderlein’s bacillus
Papanicolaou smear
clue cell
macrophage
nonspecific vaginitis
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
08
04
2020
revised:
26
05
2020
accepted:
12
06
2020
pubmed:
7
7
2020
medline:
26
8
2021
entrez:
7
7
2020
Statut:
ppublish
Résumé
Nonspecific vaginitis, also known as Bacterial vaginosis, unlike genital candidiasis and trichomoniasis, is caused by microbiome breakdown. Döderlein's bacillus are gram-positive bacillus that form a microbiome, reproduce in the female vagina after gaining sexual maturity, secrete lactic acid, and prevent the growth of other vaginitis-causing bacteria. Clue cell are squamous epithelial cells with Gardnerella sp. attached to their cell surface. The presence of clue cell is one of the diagnostic criteria for nonspecific vaginitis. Additionally, although macrophages are reported to protect against candidal vaginitis, there are no reports of studies examining the association between macrophages and clue cell. After re-staining 300 class I specimens by cervical cancer screening with Papanicolaou staining, the appearance of Döderlein's bacillus, macrophages, and clue cell was observed. Age group and appearance of Döderlein's bacillus were negatively correlated. The rate of appearance of macrophages was positively correlated with the age group. In people aged 50 years or more, the appearance rate of clue cells was significantly lower in the macrophage appearance group than that in the non-appearance group. This study suggested that macrophages, and not Döderlein's bacillus, may play an important role in defense against nonspecific vaginitis.
Sections du résumé
BACKGROUND
BACKGROUND
Nonspecific vaginitis, also known as Bacterial vaginosis, unlike genital candidiasis and trichomoniasis, is caused by microbiome breakdown. Döderlein's bacillus are gram-positive bacillus that form a microbiome, reproduce in the female vagina after gaining sexual maturity, secrete lactic acid, and prevent the growth of other vaginitis-causing bacteria. Clue cell are squamous epithelial cells with Gardnerella sp. attached to their cell surface. The presence of clue cell is one of the diagnostic criteria for nonspecific vaginitis. Additionally, although macrophages are reported to protect against candidal vaginitis, there are no reports of studies examining the association between macrophages and clue cell.
MATERIALS AND METHODS
METHODS
After re-staining 300 class I specimens by cervical cancer screening with Papanicolaou staining, the appearance of Döderlein's bacillus, macrophages, and clue cell was observed.
RESULT
RESULTS
Age group and appearance of Döderlein's bacillus were negatively correlated. The rate of appearance of macrophages was positively correlated with the age group. In people aged 50 years or more, the appearance rate of clue cells was significantly lower in the macrophage appearance group than that in the non-appearance group.
CONCLUSION
CONCLUSIONS
This study suggested that macrophages, and not Döderlein's bacillus, may play an important role in defense against nonspecific vaginitis.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1205-1210Subventions
Organisme : Niigata University of Health and Welfare
Organisme : Graduate School
Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
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