Role of microglia in the dissemination of Zika virus from mother to fetal brain.
Animals
Brain
/ virology
Disease Models, Animal
Female
Fetus
/ pathology
Humans
Infectious Disease Transmission, Vertical
Male
Mice
Mice, Inbred C57BL
Microcephaly
/ embryology
Microglia
/ metabolism
Pregnancy
Pregnancy Complications, Infectious
/ pathology
Viral Load
Zika Virus
/ isolation & purification
Zika Virus Infection
/ pathology
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
12
12
2019
accepted:
22
05
2020
revised:
16
07
2020
pubmed:
7
7
2020
medline:
19
8
2020
entrez:
7
7
2020
Statut:
epublish
Résumé
Global Zika virus (ZIKV) outbreaks and their link to microcephaly have raised major public health concerns. However, the mechanism of maternal-fetal transmission remains largely unknown. In this study, we determined the role of yolk sac (YS) microglial progenitors in a mouse model of ZIKV vertical transmission. We found that embryonic (E) days 6.5-E8.5 were a critical window for ZIKV infection that resulted in fetal demise and microcephaly, and YS microglial progenitors were susceptible to ZIKV infection. Ablation of YS microglial progenitors significantly reduced the viral load in both the YS and the embryonic brain. Taken together, these results support the hypothesis that YS microglial progenitors serve as "Trojan horses," contributing to ZIKV fetal brain dissemination and congenital brain defects.
Identifiants
pubmed: 32628667
doi: 10.1371/journal.pntd.0008413
pii: PNTD-D-19-02076
pmc: PMC7365479
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0008413Subventions
Organisme : NIAID NIH HHS
ID : R01 AI127744
Pays : United States
Organisme : NIAID NIH HHS
ID : R41 AI136126
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI129509
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142759
Pays : United States
Organisme : NIAID NIH HHS
ID : R24 AI120942
Pays : United States
Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
The authors have declared no competing financial interests.
Références
Neuron. 2017 May 17;94(4):759-773.e8
pubmed: 28521131
Science. 2016 May 13;352(6287):816-8
pubmed: 27064148
Cell Rep. 2017 Nov 7;21(6):1588-1599
pubmed: 29117563
Sci Rep. 2017 Jan 27;7:41389
pubmed: 28128342
Development. 2013 Oct;140(19):4041-50
pubmed: 24004946
Nat Rev Microbiol. 2016 Nov;14(11):707-715
pubmed: 27573577
Cell Stem Cell. 2016 Jul 7;19(1):120-6
pubmed: 27179424
Brain Behav Immun. 2018 Oct;73:682-697
pubmed: 30056204
Glia. 1993 Jan;7(1):19-24
pubmed: 7678581
J Infect Dis. 2018 Mar 28;217(8):1202-1213
pubmed: 29106643
J Ultrasound Med. 2012 Jan;31(1):87-95
pubmed: 22215774
Nat Med. 2018 Aug;24(8):1104-1107
pubmed: 29967348
J Invest Dermatol. 1991 Jul;97(1):65-72
pubmed: 1711549
PLoS One. 2018 Jan 30;13(1):e0190617
pubmed: 29381706
Cell Host Microbe. 2016 Jun 8;19(6):882-90
pubmed: 27212660
Cell Mol Life Sci. 2015 Apr;72(7):1291-302
pubmed: 25430479
Front Immunol. 2019 Sep 20;10:2199
pubmed: 31616414
Infect Immun. 2011 Aug;79(8):3046-52
pubmed: 21628522
J Neuroinflammation. 2019 Jan 31;16(1):22
pubmed: 30704498
J Neurosci Res. 2011 Mar;89(3):286-98
pubmed: 21259316
Cell Host Microbe. 2017 May 10;21(5):561-567
pubmed: 28494237
JCI Insight. 2016 Aug 18;1(13):
pubmed: 27595140
PLoS Negl Trop Dis. 2019 Feb 4;13(2):e0007071
pubmed: 30716104
Cell Host Microbe. 2016 Jul 13;20(1):83-90
pubmed: 27247001
Stem Cell Reports. 2017 Mar 14;8(3):715-727
pubmed: 28216147
MMWR Morb Mortal Wkly Rep. 2017 Jun 16;66(23):615-621
pubmed: 28617773
Am J Trop Med Hyg. 2016 Jun 1;94(6):1362-1369
pubmed: 27022155
Cell. 2008 Feb 22;132(4):631-44
pubmed: 18295580
Blood. 2003 Mar 1;101(5):1669-76
pubmed: 12406884
J Virol. 2017 Mar 29;91(8):
pubmed: 28148798
Science. 2010 Nov 5;330(6005):841-5
pubmed: 20966214
Cold Spring Harb Perspect Biol. 2015 Jul 01;7(8):a020537
pubmed: 26134003
J Comp Neurol. 1993 Apr 1;330(1):113-29
pubmed: 8468399
Cell. 2018 May 17;173(5):1111-1122.e10
pubmed: 29606355
Sci Rep. 2016 Oct 19;6:35296
pubmed: 27759009
Development. 1999 Nov;126(22):5073-84
pubmed: 10529424
Cell Stem Cell. 2016 May 5;18(5):587-90
pubmed: 26952870
N Engl J Med. 2016 Dec 15;375(24):2321-2334
pubmed: 26943629
MMWR Morb Mortal Wkly Rep. 2017 Apr 07;66(13):366-373
pubmed: 28384133
Cell Host Microbe. 2017 Sep 13;22(3):366-376.e3
pubmed: 28910635
Nat Commun. 2018 Jan 8;9(1):75
pubmed: 29311541
Cell Host Microbe. 2018 May 9;23(5):672-685.e6
pubmed: 29746837
Int J Exp Pathol. 2012 Feb;93(1):24-33
pubmed: 22264283
Front Cell Dev Biol. 2018 Jul 20;6:80
pubmed: 30079337
Cell Host Microbe. 2016 Aug 10;20(2):155-66
pubmed: 27443522
Front Cell Neurosci. 2013 Apr 17;7:45
pubmed: 23616747
Cell Rep. 2014 Sep 11;8(5):1271-9
pubmed: 25159150
J Exp Med. 2009 Dec 21;206(13):2937-46
pubmed: 19995951
Nature. 2016 May 11;534(7606):267-71
pubmed: 27279226
Physiol Genomics. 2016 Aug 1;48(8):565-72
pubmed: 27260843
Cell Host Microbe. 2016 Jun 8;19(6):891-900
pubmed: 27198478
Front Immunol. 2018 Apr 13;9:698
pubmed: 29706957
Int J Mol Sci. 2017 Aug 05;18(8):
pubmed: 28783051
Nat Med. 2016 Nov;22(11):1358-1367
pubmed: 27668937
EBioMedicine. 2017 Mar;17:145-156
pubmed: 28196656
Clin Infect Dis. 2017 Apr 1;64(7):914-920
pubmed: 28362944
Exp Hematol. 2001 Aug;29(8):927-36
pubmed: 11495698
Cell. 1985 Jul;41(3):665-76
pubmed: 2408759
Nat Commun. 2017 Feb 21;8:14575
pubmed: 28220786
Cell Rep. 2017 Jan 10;18(2):324-333
pubmed: 28076778
Science. 1988 Jan 15;239(4837):290-2
pubmed: 3276004
Biochem Biophys Res Commun. 2018 Mar 4;497(2):619-625
pubmed: 29453985
MMWR Morb Mortal Wkly Rep. 2016 Mar 11;65(9):242-7
pubmed: 26963593
J Clin Neurosci. 2010 Jan;17(1):6-10
pubmed: 19926287
Am J Obstet Gynecol. 2018 Oct;219(4):403.e1-403.e9
pubmed: 29902449
Hum Mol Genet. 2018 Jan 1;27(1):41-52
pubmed: 29048558
Nat Neurosci. 2012 Jul 26;15(8):1096-101
pubmed: 22837040
Immunity. 2015 Apr 21;42(4):665-78
pubmed: 25902481
Cell. 2016 Aug 25;166(5):1247-1256.e4
pubmed: 27565347
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7117-7122
pubmed: 29915057
Sci Immunol. 2018 Jan 5;3(19):
pubmed: 29305462
Front Hum Neurosci. 2016 Nov 08;10:566
pubmed: 27877121
J Leukoc Biol. 1990 Jul;48(1):27-37
pubmed: 2358750
Cell. 2016 May 19;165(5):1081-1091
pubmed: 27180225
J Vis Exp. 2008 Jun 27;(16):
pubmed: 19066546