Bioactive lipids, inflammation and chronic diseases.

Animals Chronic Disease Humans Inflammation / metabolism Lipid Metabolism Lipids
Chronic inflammation Eicosanoids Endocannabinoids Endogenous bioactive lipids Lysoglycerophospholipids Lysosphingolipids Resolution of inflammation Specialized pro-resolving mediators

Journal

Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523

Informations de publication

Date de publication:
2020
Historique:
received: 03 02 2020
revised: 09 06 2020
accepted: 25 06 2020
pubmed: 7 7 2020
medline: 28 8 2021
entrez: 7 7 2020
Statut: ppublish

Résumé

Endogenous bioactive lipids are part of a complex network that modulates a plethora of cellular and molecular processes involved in health and disease, of which inflammation represents one of the most prominent examples. Inflammation serves as a well-conserved defence mechanism, triggered in the event of chemical, mechanical or microbial damage, that is meant to eradicate the source of damage and restore tissue function. However, excessive inflammatory signals, or impairment of pro-resolving/anti-inflammatory pathways leads to chronic inflammation, which is a hallmark of chronic pathologies. All main classes of endogenous bioactive lipids - namely eicosanoids, specialized pro-resolving lipid mediators, lysoglycerophopsholipids and endocannabinoids - have been consistently involved in the chronic inflammation that characterises pathologies such as cancer, diabetes, atherosclerosis, asthma, as well as autoimmune and neurodegenerative disorders and inflammatory bowel diseases. This review gathers the current knowledge concerning the involvement of endogenous bioactive lipids in the pathogenic processes of chronic inflammatory pathologies.

Identifiants

DOI: 10.1016/j.addr.2020.06.028 PMID: 32628989
pubmed: 32628989
pii: S0169-409X(20)30074-0
doi: 10.1016/j.addr.2020.06.028
pii:
doi:

Substances chimiques

Lipids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

133-169

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Alessandro Leuti (A)

Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy; European Center for Brain Research/IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy.

Domenico Fazio (D)

European Center for Brain Research/IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy.

Marina Fava (M)

European Center for Brain Research/IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy; Faculty of Biosciences and Technology for Food Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.

Alessandra Piccoli (A)

Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy.

Sergio Oddi (S)

European Center for Brain Research/IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy; Faculty of Veterinary Medicine, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.

Mauro Maccarrone (M)

Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy; European Center for Brain Research/IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143 Rome, Italy. Electronic address: m.maccarrone@unicampus.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Bioactive lipids, inflammation and chronic diseases.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Bioactive lipids, inflammation and chronic diseases.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Bioactive lipids, inflammation and chronic diseases.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Bioactive lipids, inflammation and chronic diseases.
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Bioactive lipids, inflammation and chronic diseases.
questionsmedicales.fr › Lipides › Bioactive lipids, inflammation and chronic diseases.