Norcolocynthenins A and B, two cucurbitane 3-nor-Triterpenoids from Citrullus colocynthis and their cytotoxicity.

Animals Citrullus colocynthis / chemistry Glycosides / chemistry Humans Male Molecular Structure Rats Rats, Sprague-Dawley Triterpenes / chemistry
Citrullus colocynthis Cucurbitane nortriterpenoid Cytotoxicity Theoretical calculations

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
08 2020
Historique:
received: 30 04 2020
revised: 14 06 2020
accepted: 22 06 2020
pubmed: 7 7 2020
medline: 19 3 2021
entrez: 7 7 2020
Statut: ppublish

Résumé

Two novel cucurbitane 3-nor-triterpenoids, named norcolocynthenins A (1) and B (2), were isolated from the fruits of Citrullus colocynthis. The structures including their absolute configurations were determined by extensive spectroscopic analyses and theoretical calculations. Compound 1 features an unprecedented 5/6/6/5-fused ring system while compound 2 possesses a rare lactone moiety at modified ring A. Compounds 1 and 2 showed significant cytotoxic activity against human cancer cell lines of HL-60 (IC

Identifiants

DOI: 10.1016/j.bioorg.2020.104045 PMID: 32629288
pubmed: 32629288
pii: S0045-2068(20)31342-0
doi: 10.1016/j.bioorg.2020.104045
pii:
doi:

Substances chimiques

Glycosides 0
Triterpenes 0
cucurbitane 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104045

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Yushuang Liu (Y)

The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang330022, China; The Key Laboratory of Plant Resources and Chemistry of Arid Zone, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, United States.

Lu Zhang (L)

The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang330022, China.

Jingjing Xue (J)

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Kaibo Wang (K)

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, United States.

Huiming Hua (H)

Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Tao Yuan (T)

The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang330022, China; The Key Laboratory of Plant Resources and Chemistry of Arid Zone, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. Electronic address: tyuan@jxnu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Norcolocynthenins A and B, two cucurbitane...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Cucurbitaceae › Citrullus › Citrullus colocynthis › Norcolocynthenins A and B, two cucurbitane...
questionsmedicales.fr › Glucides › Hétérosides › Norcolocynthenins A and B, two cucurbitane...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Norcolocynthenins A and B, two cucurbitane...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Norcolocynthenins A and B, two cucurbitane...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Norcolocynthenins A and B, two cucurbitane...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Norcolocynthenins A and B, two cucurbitane...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Norcolocynthenins A and B, two cucurbitane...