Malaria Elimination in Costa Rica: Changes in Treatment and Mass Drug Administration.
Anopheles albimanus
Costa Rica
Plasmodium vivax
illegal mining
malaria
migration
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
30 Jun 2020
30 Jun 2020
Historique:
received:
17
04
2020
revised:
04
05
2020
accepted:
11
05
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
8
7
2020
Statut:
epublish
Résumé
Costa Rica is a candidate to eliminate malaria by 2020. The remaining malaria transmission hotspots are located within the Huétar Norte Region (HNR), where 90% of the country's 147 malaria cases have occurred since 2016, following a 33-month period without transmission. Here, we examine changes in transmission with the implementation of a supervised seven-day chloroquine and primaquine treatment (7DCPT). We also evaluate the impact of a focal mass drug administration (MDA) in January 2019 at Boca Arenal, the town in HNR reporting the greatest local transmission. We found that the change to a seven-day treatment protocol, from the prior five-day program, was associated with a 98% reduction in malaria transmission. The MDA helped to reduce transmission, keeping the basic reproduction number,
Identifiants
pubmed: 32630155
pii: microorganisms8070984
doi: 10.3390/microorganisms8070984
pmc: PMC7409053
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Universidad de Costa Rica, Vicerrectoria de Investigación
ID : Proyecto B9 464
Organisme : Vigilancia de la Salud, Ministerio de Salud
ID : SN
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