Non-Muscle Myosin 2A (NM2A): Structure, Regulation and Function.
Actomyosin
/ metabolism
Animals
Cell Adhesion
/ genetics
Cell Membrane
/ genetics
Cell Movement
/ genetics
Cytoskeleton
/ metabolism
Embryonic Development
/ genetics
Humans
Kidney Diseases
/ genetics
Myosin Heavy Chains
/ chemistry
Myosins
/ metabolism
Neoplasms
/ genetics
Neurodegenerative Diseases
/ genetics
NM2A activity regulation
NM2A filament assembly
actomyosin cytoskeleton
cell adhesion
cell migration
non-muscle myosin 2A (NM2A)
plasma membrane blebbing
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
received:
19
05
2020
revised:
25
06
2020
accepted:
29
06
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
23
3
2021
Statut:
epublish
Résumé
Non-muscle myosin 2A (NM2A) is a motor cytoskeletal enzyme with crucial importance from the early stages of development until adulthood. Due to its capacity to convert chemical energy into force, NM2A powers the contraction of the actomyosin cytoskeleton, required for proper cell division, adhesion and migration, among other cellular functions. Although NM2A has been extensively studied, new findings revealed that a lot remains to be discovered concerning its spatiotemporal regulation in the intracellular environment. In recent years, new functions were attributed to NM2A and its activity was associated to a plethora of illnesses, including neurological disorders and infectious diseases. Here, we provide a concise overview on the current knowledge regarding the structure, the function and the regulation of NM2A. In addition, we recapitulate NM2A-associated diseases and discuss its potential as a therapeutic target.
Identifiants
pubmed: 32630196
pii: cells9071590
doi: 10.3390/cells9071590
pmc: PMC7408548
pii:
doi:
Substances chimiques
MYH9 protein, human
0
Actomyosin
9013-26-7
Myosin Heavy Chains
EC 3.6.4.1
Myosins
EC 3.6.4.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Dev Cell. 2018 Aug 6;46(3):257-270.e5
pubmed: 30032990
Blood. 2012 Jan 5;119(1):238-50
pubmed: 21908426
Behav Neurosci. 2009 Feb;123(1):218-23
pubmed: 19170447
Curr Biol. 2015 Feb 2;25(3):402
pubmed: 29665398
Am J Transl Res. 2019 Sep 15;11(9):5301-5312
pubmed: 31632511
Curr Biol. 2020 Jul 6;30(13):2446-2458.e6
pubmed: 32502416
J Cell Biol. 1997 Oct 20;139(2):397-415
pubmed: 9334344
Mol Biol Cell. 2007 Aug;18(8):3144-55
pubmed: 17567956
Dev Cell. 2011 Mar 15;20(3):e1
pubmed: 21411393
Exp Cell Res. 2014 Aug 15;326(2):295-306
pubmed: 24768700
Curr Opin Cell Biol. 2019 Feb;56:53-63
pubmed: 30278304
J Microsc. 2008 Sep;231(3):466-78
pubmed: 18755002
CNS Neurosci Ther. 2013 Aug;19(8):603-10
pubmed: 23638992
PLoS One. 2012;7(4):e35986
pubmed: 22558294
Rinsho Byori. 2003 Sep;51(9):898-904
pubmed: 14560660
J Alzheimers Dis. 2010;20(4):1003-8
pubmed: 20413901
Front Microbiol. 2019 Mar 04;10:401
pubmed: 30886609
Mol Biol Cell. 2006 Jul;17(7):2869-81
pubmed: 16611744
Philos Trans R Soc Lond B Biol Sci. 2018 May 26;373(1747):
pubmed: 29632266
Commun Integr Biol. 2017 Sep 28;10(5-6):e1349582
pubmed: 29259728
Mol Biol Cell. 2007 Jun;18(6):2305-12
pubmed: 17429076
Mol Biol Cell. 2001 Apr;12(4):780-94
pubmed: 11294886
Mol Biol Cell. 2009 Jan;20(1):338-47
pubmed: 18971378
Nat Genet. 2000 Sep;26(1):106-8
pubmed: 10973260
Blood. 1991 Oct 1;78(7):1826-33
pubmed: 1912569
Lab Invest. 2010 Mar;90(3):448-58
pubmed: 20065948
Blood. 2007 Jul 1;110(1):171-9
pubmed: 17392504
Nature. 1980 Sep 18;287(5779):233-5
pubmed: 6893621
PLoS Pathog. 2010 Dec 23;6(12):e1001238
pubmed: 21203488
Ciba Found Symp. 1973;14:233-49
pubmed: 4492795
Nat Rev Mol Cell Biol. 2009 May;10(5):353-9
pubmed: 19373240
Biochemistry. 1998 Feb 17;37(7):1989-2003
pubmed: 9485326
Mol Biol Cell. 2007 Dec;18(12):5081-90
pubmed: 17928407
Curr Biol. 2015 Mar 30;25(7):942-8
pubmed: 25754640
Annu Rev Cell Dev Biol. 2012;28:29-58
pubmed: 22804577
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Mol Biol Cell. 2013 Mar;24(6):757-67
pubmed: 23345594
Genome Biol. 2007;8(9):R196
pubmed: 17877792
Bioarchitecture. 2014;4(6):169-88
pubmed: 26155737
Nature. 2005 May 19;435(7040):365-9
pubmed: 15902261
Curr Opin Cell Biol. 2017 Aug;47:99-107
pubmed: 28511145
Mol Genet Genomic Med. 2014 Jul;2(4):297-312
pubmed: 25077172
Dev Cell. 2016 Jul 25;38(2):161-9
pubmed: 27459068
Nat Genet. 2000 Sep;26(1):103-5
pubmed: 10973259
Mol Biol Cell. 2018 Mar 1;29(5):622-631
pubmed: 29282285
Hum Mutat. 2014 Feb;35(2):236-47
pubmed: 24186861
J Biol Chem. 2005 May 20;280(20):19594-9
pubmed: 15774463
J Biol Chem. 2003 Jul 25;278(30):27439-48
pubmed: 12704189
Curr Opin Cell Biol. 2008 Feb;20(1):41-7
pubmed: 18226515
Bioarchitecture. 2014;4(3):88-102
pubmed: 25098841
Cell Mol Life Sci. 2013 Jan;70(1):1-21
pubmed: 22565821
Cancer Res. 2006 May 1;66(9):4725-33
pubmed: 16651425
Structure. 2012 Apr 4;20(4):654-66
pubmed: 22483112
Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H191-9
pubmed: 19429828
Mol Biol Cell. 2012 Feb;23(4):591-601
pubmed: 22219375
J Hum Genet. 2001;46(12):722-9
pubmed: 11776386
J Biol Chem. 2004 Jan 23;279(4):2800-8
pubmed: 14594953
Nat Cell Biol. 2013 Mar;15(3):325-34
pubmed: 23417121
Eur J Cell Biol. 2011 Jan;90(1):37-48
pubmed: 21087809
J Biol Chem. 2005 Jun 17;280(24):22769-75
pubmed: 15845534
Biochemistry. 2005 May 10;44(18):6867-76
pubmed: 15865432
Curr Biol. 2012 Jun 5;22(11):956-66
pubmed: 22560610
PLoS One. 2015 Mar 31;10(3):e0121460
pubmed: 25826333
Science. 2003 Mar 14;299(5613):1743-7
pubmed: 12637748
J Biol Chem. 1981 Dec 25;256(24):13137-42
pubmed: 6118372
Curr Opin Cell Biol. 1997 Feb;9(1):44-8
pubmed: 9013666
J Biol Chem. 2013 Mar 29;288(13):9532-48
pubmed: 23382379
J Biol Chem. 1986 Jan 5;261(1):36-9
pubmed: 3079756
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14645-50
pubmed: 20679233
Dis Model Mech. 2015 Dec;8(12):1495-515
pubmed: 26542704
J Cell Biol. 2010 Mar 22;188(6):877-90
pubmed: 20308429
J Cell Sci. 2006 Sep 15;119(Pt 18):3833-44
pubmed: 16926192
Biochemistry (Mosc). 2018 Dec;83(12):1459-1468
pubmed: 30878021
Dev Cell. 2017 Nov 20;43(4):480-492.e6
pubmed: 29107560
Nat Rev Mol Cell Biol. 2017 Dec;18(12):743-757
pubmed: 29115298
Elife. 2014 Sep 15;3:e03159
pubmed: 25225054
Curr Biol. 2019 Jan 7;29(1):81-92.e5
pubmed: 30581023
Medicine (Baltimore). 2003 May;82(3):203-15
pubmed: 12792306
J Biol Chem. 2013 Jan 4;288(1):709-22
pubmed: 23148220
J Biol Chem. 2012 May 4;287(19):15330-44
pubmed: 22399300
Atherosclerosis. 2009 Nov;207(1):68-73
pubmed: 19473657
Nature. 2005 Aug 25;436(7054):1113-8
pubmed: 16121172
Physiology (Bethesda). 2005 Aug;20:239-51
pubmed: 16024512
Nat Cell Biol. 2010 Jul;12(7):696-702
pubmed: 20543839
J Mol Biol. 1975 Nov 25;99(1):1-14
pubmed: 128633
Ann Neurol. 2013 Nov;74(5):709-20
pubmed: 23818336
Cell Mol Life Sci. 2019 Apr;76(7):1319-1339
pubmed: 30591958
Behav Brain Res. 2013 Apr 15;243:171-5
pubmed: 23327740
Am J Hum Genet. 2001 Nov;69(5):1033-45
pubmed: 11590545
PLoS One. 2008 Sep 18;3(9):e3234
pubmed: 18800171
Br J Cancer. 2017 Aug 8;117(4):563-571
pubmed: 28664914
J Mol Biol. 1996 Jan 12;255(1):98-109
pubmed: 8568878
Thromb Haemost. 2009 Jul;102(1):90-6
pubmed: 19572073
Nat Rev Mol Cell Biol. 2009 Nov;10(11):778-90
pubmed: 19851336
J Cell Sci. 1994 Nov;107 ( Pt 11):3077-90
pubmed: 7699007
Glia. 2014 Feb;62(2):217-32
pubmed: 24311453
Lab Invest. 2003 Jan;83(1):115-22
pubmed: 12533692
J Biol Chem. 1984 Jul 25;259(14):8808-14
pubmed: 6235218
Elife. 2016 Oct 10;5:
pubmed: 27719759
Nephrol Dial Transplant. 2013 Dec;28(12):2993-3003
pubmed: 24042022
Semin Cell Dev Biol. 2011 Dec;22(9):961-7
pubmed: 22001381
J Biol Chem. 2015 Mar 27;290(13):8383-95
pubmed: 25635050
Theranostics. 2017 Aug 2;7(13):3338-3353
pubmed: 28900514
Am J Hum Genet. 2000 Nov;67(5):1121-8
pubmed: 11023810
J Cell Sci. 1998 Aug;111 ( Pt 15):2085-95
pubmed: 9664030
J Biochem. 2003 Apr;133(4):405-13
pubmed: 12761286
Cells. 2020 Jun 12;9(6):
pubmed: 32545517
Curr Biol. 2018 Apr 23;28(8):R392-R397
pubmed: 29689221
Dev Cell. 2017 Jul 24;42(2):143-155.e5
pubmed: 28712722
Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9616-20
pubmed: 18599451
Toxins (Basel). 2019 Jul 17;11(7):
pubmed: 31319618
Dev Cell. 2014 Jul 28;30(2):209-23
pubmed: 25073157
Cell Biochem Biophys. 1999;30(3):389-411
pubmed: 10403058
Biochemistry. 1997 Dec 23;36(51):16321-7
pubmed: 9405067
Gene. 2003 Jul 17;312:165-71
pubmed: 12909352
Cell. 2015 Feb 12;160(4):673-685
pubmed: 25679761
J Biol Chem. 1992 Sep 5;267(25):17864-71
pubmed: 1355479
Cancer Res. 2006 May 15;66(10):5173-80
pubmed: 16707441
Traffic. 2016 Aug;17(8):839-59
pubmed: 26929436
Nat Genet. 2012 Dec;44(12):1382-7
pubmed: 23143599
Elife. 2018 Feb 08;7:
pubmed: 29419377
J Cell Biol. 2008 Dec 15;183(6):999-1005
pubmed: 19075110
J Cell Biol. 2016 Nov 21;215(4):445-456
pubmed: 27872252
Mol Biol Cell. 2016 Mar 9;:
pubmed: 26960797
Front Immunol. 2019 Apr 12;10:747
pubmed: 31031752
J Biol Chem. 2003 Oct 3;278(40):38132-40
pubmed: 12847096
J Cell Biol. 2013 Jun 24;201(7):1069-84
pubmed: 23798731
Nat Cell Biol. 2017 Feb;19(2):133-141
pubmed: 28114270
Handb Exp Pharmacol. 2017;235:77-122
pubmed: 27757761
J Cell Sci. 2000 Apr;113 ( Pt 7):1287-98
pubmed: 10704379
Nat Cell Biol. 2017 Feb;19(2):85-93
pubmed: 28114272
Essays Biochem. 2019 Oct 31;63(5):497-508
pubmed: 31551323
Cell Motil Cytoskeleton. 2008 Jan;65(1):12-24
pubmed: 17896341
J Cell Sci. 2008 Jan 1;121(Pt 1):11-8
pubmed: 18096687
Curr Biol. 2014 Sep 8;24(17):1958-68
pubmed: 25131674
Hum Mutat. 2008 Mar;29(3):409-17
pubmed: 18059020
Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6918-23
pubmed: 20351273
Cell Death Dis. 2013 Dec 12;4:e959
pubmed: 24336079
Circ Res. 1991 Aug;69(2):530-9
pubmed: 1860190
Development. 2009 Jun;136(12):1977-86
pubmed: 19439495
Annu Rev Biophys Biomol Struct. 2006;35:417-34
pubmed: 16689643
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12747-8
pubmed: 9398068
J Biol Chem. 2011 Jun 17;286(24):21191-202
pubmed: 21478157
Development. 2019 Nov 12;146(21):
pubmed: 31582415
J Cell Biol. 2007 Feb 26;176(5):573-80
pubmed: 17312025
Biochem Soc Trans. 2011 Oct;39(5):1131-5
pubmed: 21936777
Biophys J. 2008 Mar 1;94(5):1836-53
pubmed: 17921219
J Cell Biol. 1976 Dec;71(3):848-75
pubmed: 62755
Biochemistry. 2014 Jan 21;53(2):350-60
pubmed: 24393048
Nature. 2010 Jan 28;463(7280):485-92
pubmed: 20110992
EMBO J. 2018 Sep 3;37(17):
pubmed: 30049714
Nat Cell Biol. 2002 Jan;4(1):83-8
pubmed: 11744924
Science. 2014 Jan 17;343(6168):309-13
pubmed: 24436421
PLoS One. 2013 Jul 26;8(7):e70636
pubmed: 23923011
Small GTPases. 2017 Apr 3;8(2):85-89
pubmed: 27314434
J Cell Sci. 2016 Mar 15;129(6):1093-100
pubmed: 26919980
J Biomed Biotechnol. 2010;2010:858606
pubmed: 20625425
Proc Natl Acad Sci U S A. 1989 Oct;86(20):7726-30
pubmed: 2813355
J Biol Chem. 2013 Nov 15;288(46):33398-410
pubmed: 24072716
Nat Rev Mol Cell Biol. 2008 Sep;9(9):730-6
pubmed: 18628785
Curr Opin Cell Biol. 2009 Apr;21(2):140-6
pubmed: 19269802
Nat Cell Biol. 2007 Mar;9(3):299-309
pubmed: 17310241
J Cell Sci. 2012 Apr 1;125(Pt 7):1627-32
pubmed: 22566666
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18581-6
pubmed: 19846787
Mol Biol Cell. 2004 Mar;15(3):982-9
pubmed: 14699073
J Cell Biol. 2015 Aug 17;210(4):583-94
pubmed: 26261182
J Cell Biol. 1977 Jul;74(1):251-63
pubmed: 141455
J Biol Chem. 2004 Oct 1;279(40):41263-6
pubmed: 15292239
Eur J Haematol. 2010 Apr;84(4):291-7
pubmed: 20002731
J Biol Chem. 1996 Feb 2;271(5):2689-95
pubmed: 8576242
Orphanet J Rare Dis. 2014 Jun 30;9:100
pubmed: 24980457
Dev Biol. 1980 Jan;74(1):152-72
pubmed: 6765932
Brain. 2012 Nov;135(Pt 11):3355-70
pubmed: 23087045
BMC Cell Biol. 2011 Dec 02;12:52
pubmed: 22136066
J Biol Chem. 1989 Jan 25;264(3):1431-6
pubmed: 2521481
Biochim Biophys Acta. 2000 Mar 17;1496(1):3-22
pubmed: 10722873
J Mol Biol. 2016 May 8;428(9 Pt B):1927-46
pubmed: 26827725
Biochim Biophys Acta. 2008 Mar;1778(3):660-9
pubmed: 17854762
Biochem J. 2011 Feb 15;434(1):171-80
pubmed: 21126233
Mol Biol Cell. 2019 Apr 15;30(9):1051-1059
pubmed: 30785846
J Neurol Sci. 2015;353(1-2):28-37
pubmed: 25908255
Nature. 1996 Aug 1;382(6590):455-8
pubmed: 8684486
Mol Psychiatry. 2016 Feb;21(2):298
pubmed: 25939403
Mol Biol Cell. 2008 Aug;19(8):3357-68
pubmed: 18495866
Br J Haematol. 1988 Dec;70(4):441-8
pubmed: 2851314
J Cell Biol. 2006 Nov 6;175(3):477-90
pubmed: 17088428
Trends Cell Biol. 2009 Jun;19(6):245-52
pubmed: 19406643
J Cell Biol. 2007 Dec 17;179(6):1141-8
pubmed: 18086913
Mol Biol Cell. 2007 Oct;18(10):3723-32
pubmed: 17634292
Cell. 2015 Feb 12;160(4):659-672
pubmed: 25679760
J Cell Biol. 2017 Sep 4;216(9):2877-2889
pubmed: 28701425
Gene. 2018 Jul 20;664:152-167
pubmed: 29679756
Biochemistry. 1991 Jan 29;30(4):966-70
pubmed: 1899200
Int J Dev Biol. 2011;55(7-9):835-40
pubmed: 22161839
Biophys J. 2006 Nov 15;91(10):3907-20
pubmed: 16920834
Genomics. 2004 Jun;83(6):1125-33
pubmed: 15177565
DNA Cell Biol. 2008 Mar;27(3):117-25
pubmed: 17997715
Elife. 2019 Sep 05;8:
pubmed: 31486768
Am J Physiol Heart Circ Physiol. 2014 Apr 15;306(8):H1192-203
pubmed: 24486510
Eur J Biochem. 1989 Oct 1;184(3):611-6
pubmed: 2806244
PLoS One. 2016 Mar 01;11(3):e0150004
pubmed: 26930466
J Cell Biol. 1987 May;104(5):1309-23
pubmed: 3032987
Cell Mol Life Sci. 2008 Sep;65(18):2790-800
pubmed: 18726179
Science. 1987 May 29;236(4805):1086-91
pubmed: 3576222
PLoS One. 2007 Aug 01;2(7):e658
pubmed: 17668046
EMBO Rep. 2017 Feb;18(2):303-318
pubmed: 28039206
J Cell Biol. 2010 Jan 25;188(2):287-97
pubmed: 20100912
J Cell Biol. 2008 Jun 16;181(6):879-84
pubmed: 18541702