Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances.
Alzheimer’s disease
Parkinson’s disease
computer-aided drug discovery
ischemic stroke
neuroprotection
seaweed
secondary metabolites
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
01 Jul 2020
01 Jul 2020
Historique:
received:
20
05
2020
revised:
19
06
2020
accepted:
25
06
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
30
4
2021
Statut:
epublish
Résumé
Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. As was evident in various preclinical studies, algal compounds conferred neuroprotection against a wide range of neurotoxic stressors, such as oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP
Identifiants
pubmed: 32630301
pii: md18070347
doi: 10.3390/md18070347
pmc: PMC7401253
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : 2018R1A2B6002232
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